How Long Does it Take M3 to Start Working?

How long does it take M3 to work? I think what people are really asking is how long before they see any change or any differences. So, it starts to work right away but as far as how they might feel what we see consistently and a lot of this depends on their age and their health history as well as you know the type of issues that they're dealing with at the time, but consistently what we find is that people who use especially the 40 year olds and over because as we know they have less nitric oxide that they're producing but they start to notice that their energy improves and this no doubt is due to the more oxygenation that they get because nitric oxide is one part oxygen. So they get more oxygenation as well as the mitochondria converts the amino acids arginine and citrulline which there's a heavy amount of those in M3.

It converts those into cellular energy and so people notice this energy boost but they also notice that they sleep better and that's because arginine is a precursor to human growth hormone. Before you go to bed these HGH levels should be optimal and as you go through your night's sleep the HGH helps for you to have a good restorative recuperative sleep so that you wake up feeling refreshed. Those are the two things that people start to notice right away. As far as long-term issues like blood pressure that may take a few days or up to a few weeks before that starts to respond and again that's because your arteries need to get more bounce in them or flexibility and so it takes a little time for those vasodilation effects to really take place and to have those type of benefits. With cholesterol and triglycerides again we start to see those things respond in about six months that's how long we recommend people wait before they get their lipids checked again.

As far as plaque regression which we have all the studies to show that nitric oxide does cause plaque to regress and again that's something that may take several months or years depending on their response again everybody is different on how they respond so what we do use is a little plethysmography meter that just sticks on the fingertip and it shows how healthy a person is far as their arteries are concerned. From a1 to a7 and consistently we see over a period of 90 days after we screen them that we start to see improvement 90% of time they show improvement after 90 days after taking the product as recommended. So many of you have been using M3 you're seeing great results for those that are still kicking the tires and wondering well we recommend that you give it a try at of course a 100% money-back guarantee, if it doesn't work the way that you want it to and see what it will do for you and we look forward to hearing your great story down the road!

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Arginine vs. Beet Juice

How is it that beets create nitric oxide? What is the difference between beets and arginine? For starters, both beets and arginine as well as citrulline create nitric oxide. In fact spinach and other vegetables with nitrates also product nitric oxide. So how do they differ? What is the mechanism by which they work?


Lets talk about beets first of all. Beets are high in nitrates. Just like other vegetables high in nitrates like spinach and kale, your own bacteria located in your mouth help convert them into nitrites via good bacteria and good PH. So from nitrates to nitrites thanks to your own good flora is the first process on the way to become nitric oxide. One the nitrites enter the digestive tract and are absorbed they are converted again into nitrates. The nitrates are then converted in to nitric oxide and enter the blood stream. This is the point where nitric oxide can do all the amazing things this miracle molecule is known for.


So how are beets and other vegetable sources of nitrates different from arginine?
When your body takes in arginine through various means like proteins. Products like hamburgers have somewhere between three to five grams of arginine. Most other meats and even beans like soybeans have various amounts of arginine. I myself like to consume arginine via supplements. In the body it's absorbed into the small intestine. Here is where it is taken into the blood stream and once it hits the endothelium of the arteries it's converted into nitric oxide. So the two substances, beets and arginine have two different methods of being converted into nitric oxide in the body.

Arginine vs beetroot powder - Which is better?

Really both are excellent ways for your body to get nitric oxide. However, after getting involved in the nitric oxide world back in 2005 the big deal was arginine at the time. During that time in my personal practice I saw great results from people using arginine based products. Arginine has been my personal supplement of choice then for quite a while. Some people point to a study that says people past 40 don't or can't absorb arginine. This has not been my personal experience at all. I have had patients as old as 90 get fantastic results when taking the right product. Having the right5 mix of compounds like citrulline and other absorption factors is key. Arginine is a great way to make nitric oxide. The recommended dosage is at least 5 grams a day. The beet nitrate pathway however is also a great way to boost your nitric oxide levels. The majority of the studies however have been done with Arginine, due to the Nobel Prize wining original studies that primarily focused on arginine.

Using a combination of the two, beetroot powder and arginine is a great way to get the best from both. For just that reason I personally include both arginine and beetroot powder in my own product called M3 Ultimate Nitric Oxide Nutrition and have also created Nox3 Greens.

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Nitric Oxide for Weight Loss

Nitric Oxide is a miracle molecule when it comes to heart health. It's actively used in treatments for a range of problems from Alzheimer's disease and depression to congestive heart failure. Did you know Nitric Oxide can also help you lose weight? Let’s see how we can use Nitric Oxide for weight loss.

Nitric Oxide has been shown to increase fat loss several studies. Your muscles are living tissue. They generate heat, move you around and therefore burn calories. It takes energy to maintain muscle. For those who go to the gym and exercise, this means a faster metabolism.

Nitric oxide is known as vasodilator. A vasodilator expands your blood vessels and arteries. This allows more blood and oxygen to flow to your body’s tissues, organs and muscles. Increased blood flow also means an increased ability to remove toxins and to take in nutrients. The combination of faster toxin removal and nutrient uptake translates into quicker recovery time. Quicker recovery time means more mobility, more time to train and more calories burned.

One of the toxins that is produced during strenuous exercise is lactic acid. If you have ever felt your muscles burn after or during an exercise, this is due usually to lactic acid build up. When too much lactic acid builds up, you just have to stop. It can prevent muscle contraction and it's painful.

Having high levels of N.O. prevents buildup of lactic acid. Since having less lactic acid means being able to do more exercise, nitric oxide directly maps to more calories being burned via longer walking, running, sporting or gym time. It also allows the muscle to grow more. Since muscle burns calories even while you sleep, this results in a faster metabolism.

We believe that we have created the BEST nitric oxide formula to date. Nothing works better. M3 Ultimate Nitric Oxide Nutrition is so powerful it is prescribed by doctors all over the world! Use the code below to save on your first bottle on!

Senior man exercising on treadmill and his personal trainer motivating him at rehab gym. Instructor giving motivation to old man walking on treadmill.

Turmeric and Curcumin

Turmeric and Curcumin – The Worlds most powerful pharmaceutical herb!

Turmeric is a main ingredient in curry powder. IT has been called one of the most powerful disease fighting plants known to man! Interest in Curcumin, the main chemical constituent of turmeric has grown wildly recently. This has been in no small part due to the fact that over  6,235 peer-reviewed articles have found time and time again that it is in fact a miracle worker in the body.

Many of these studies have come to an extremely interesting conclusion. When compared to the efficacy of pharmaceutical drugs, curcumin equaled or almost equaled the effects of actual prescription medication. Some studies suggest it is even more beneficial due to it’s lack of side effects.

Here are just a few of the many drugs Turmeric has been reported to match or beat.

Aspirin, Ibuprofen, Naproxen and Celecoxib, Metformin, Azathioprine and mercaptopurine, Prozac and other SSRIs, Corticosteroids, DMARDs and many more.

How does Curcumin do so many things?

Curcumin helps ease inflammation by blocking the effects of two enzymes in the body which cause inflammation. The two enzymes, 5-lipoxygenase and cyclooxygenase-2, have been found to encourage and sustain swelling and inflammation in the human body. Blocking these enzymes reduces pain and the risk of other medical conditions that develop as a result of inflammation.

What are some of these conditions?

  • Heart Disease, High blood pressure, High cholesterol levels
  • Alzheimer’s Disease
  • Cancer
  • Diabetes
  • Chronic Peptic Ulcer
  • Rheumatoid Arthritis
  • Chronic Periodontitis
  • Ulcerative Colitis and Crohn's Disease
  • Chronic Sinusitis
  • Chronic Hepatitis

Turmeric For Heart Disease

The medical community in general has shown little interest in curcumin and it's role in heart health. This is despite the many and varied studies proving again and again it's benefit. Curcumin has been called and proven to be a cardioprotective substance.

In one study published in the American Journal of Cardiology, they showed that turmeric extract reduced post-bypass heart attack risk by 56%. Another study published by the journal Nutrition Research in 2012 showed that curcumin, the primary polyphenol in turmeric was as effective as exercise in improving circulatory function in postmenopausal women. Those impressive results have caused some to call curcumin "exercise in a bottle".

Another compelling new study found in the Journal of Nutrition and Metabolism has shown that a daily dose of curcumin significantly improved the blood vessels of healthy adults within a span of two months. The study shed light on what is believed to be the central cause of cardiovascular disease, the inability of the inner lining of blood vessels to open (vasodilation).

Since curcumin has such a great effect on the heart, it makes perfect sense to include it with a nitric oxide booster as it's effects are synergistic.

Turmeric & Cancer

Many studies have proven that curcumin helps prevent various types of cancer including lung, stomach, breast, hepatic (liver) and colon. It halts cancer growth by interfering with the cellular signaling cancer uses to grow.
Studies have proven curcumin can…

  • Kill lymphoma cells
  • Inhibit COX-2, an inflammatory enzyme which can increase cancer risk
  • Preventing regrowth of cancer stem cells
  • Starve cancer cells of their oxygen and fuel source
  • Turn on anti tumor genes
  • Stop metastasis of cancer cells

Curcumin is not well absorbed in the blood but it is in the colon , this fact gives it a distinct advantage in fighting cancerous tissues in the colon. Curcumin also tackles prostate cancer by modulating sex hormone receptors in the prostate gland. It has also been shown to be effective in the prevention of cervical cancer. Curcumin’s anti-inflammatory property blocks the human papilloma virus and activates cancer cell death within the uterine lining.

Curcumin for Diabetes

Many studies suggest that curcumin can in fact decrease the level of blood glucose. Researchers also reported that curcumin may also be effective for diabetes prevention. It has been found that turmeric extract stabilizes blood sugar levels and in turn makes diabetes more easily controllable.
One very interesting study, published by the American Diabetic Association found turmeric extract to be 100% effective in preventing pre-diabetics from developing type 2 diabetes. You would think this would be all over the news. Sadly, the pharmaceutical industry can make no money from this, and they need you to be sick to exist.

Chronic peptic ulcers

Curcumin may also help people with ulcers. There is a big caveat here. It all depends on what the cause of the ulcers is. If it's high stomach acid, some studies show that it will not help. If however, you are like many and have as a root cause the Helicobacter pylori bacterial infection, which is causing the ulcer, then turmeric is your friend.

The Helicobacter pylori bacteria cause peptic ulcers. Treatment can be difficult and currently available medications do not help to ease symptoms. In a recent study curcumin was show to stop growth of all the H.pylori types and strains. Mice infected with H.pylori were given curcumin and were shown to be protected from gastric damage by curcumin intake. This study proves that turmeric has potential in treating H.pylori infections and diseases caused by it such as gastritis.

Curcumin and Rheumatoid Arthritis

Several recent studies have shown curcumin to have anti-inflammatory abilities and have proven it's role in modification of immune system responses. A 2010 clinical trial found that a curcumin supplement provided long-term improvement in pain and functionality. A study done in 2012 on people with active rheumatoid arthritis showed that the individuals who were given curcumin saw decreased Disease Activity Scores as well as a decrease in the number of tender and/or swollen joints over the group not given curcumin. In addition, no adverse effects were seen in the individuals taking curcumin.

Turmeric and Chronic Periodontitis

In a recent study  Twenty-five patients participated in a trial of two randomized groups. All had been diagnosed with chronic periodontitis. In this study curcumin was inserted deep within the periodontal pockets, and sites were covered with periodontal dressings. In the end, the curcumin gel group yielded significant improvement over the control group when comparing them against one another via intergroup analysis. These results tended to gain in statistical significance in later time intervals, implying continued improvements over time and with multiple applications of curcumin.

In the past few years several studies have substantiated curcumin’s effectiveness and supported its therapeutic potential as an armament to protect patients from the ravages of serious and chronic disease.

Ulcerative Colitis and Crohn's Disease

A study was conducted on curcumin and its  benefits for patients with ulcerative colitis.  The study was was a randomized, double-blind, multi-center trial. 45 patients were given 1g curcumin after breakfast and a similar dosage after the evening meal.  It was determined based on endoscopy examinations and through a symptom rating scale that those treated with curcumin suffered fewer disease symptoms on an average compared to those given the placebo. The conclusion was made that turmeric is a safe and promising medication that may be used in the treatment of quiescent ulcerative colitis.

Another study was done to determine the use of curcimon in the prevention of ulcerative colitis. Male Swiss albino rats were given dextran sulfate sodium (DSS) for 5 days to induce colitis. One group was given 100mg/kg curcumin for 7 days before being given DSS. The rats being given curcumin suffered less weight loss than the control group. Typical symptoms of ulcerative colitis that were induced by DSS like infiltration of inflammatory cells, thickening of intestinal walls and mucosal ulceration were much reduced. Researchers believed that the reason could be the antioxidant properties of turmeric and inhibition of NF kappa-B a cellular inflammatory agent. Curcumin may play a protective role by regulating anti-oxidant balance and modulating release of certain inflammatory endocoids in cases of ulcerative colitis. It was also found that even small doses of < 0.25% turmeric was sufficient to provide protection and this could be got by including this spice in food.

Curcumin and Chronic Sinusitis

When the nasal tissues are inflamed (sinusitis), the airways are blocked, trapping the mucus in the sinuses. The trapped mucus then creates an environment that is perfect for growth of bacteria and viruses. The Trapped mucus then places excessive pressure on the surrounding areas of your head causing pain and inflammation. Since curcumin reduces inflammation and may even reduce the allergic symptoms that caused the sinusitis in the first place, curcumin works on all fronts to reduce the swelling and inflammation.

Curcumin and Chronic Hepatitis

Turmeric has a unique property that helps fight the Hepatitis C virus. Although it may not be as potent as one of the new Hepatitis C antiviral drug combinations, a study published in a 2014 edition of the journal Gut evaluated affordable antiviral strategies targeting the early stages of Hepatitis C infection.

The researchers looked at the potency of turmeric as a Hepatitis C entry inhibitor. They determined that turmeric inhibited Hepatitis C entry regardless of viral genotype. In human liver cells, the researchers concluded that turmeric affected membrane fluidity by impairing Hepatitis C virus binding and fusion. Supplementing with turmeric provides an inexpensive means of protecting liver cells from being infected with Hepatitis C.
Some doctors are being advised now that curcumin supplementation is indicated during both Hepatitis B and C infection and during their treatments.

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What is better for the heart: CoQ10 or Arginine?

As far as my heart health is concerned which is better to take  CoQ10 or the amino acid l-arginine?

So the answer is that they work in different ways and both are great.  But let's talk about the difference.

Hello Jay Wilkins here.
Nitric oxide enthusiast as well as nitric oxide supplement formulator and I'm here to talk about a really good question that came across my desk the other day from somebody that wanted to know:


We will start there. It's a ubiquitous chemical or molecule in your body that is used to really help your cells to make cellular energy. So it causes the mitochondria then to  generate ATP energy and what cells in your body have the most mitochondria and the most need for creating ATP? It is your muscles. Your muscles because of what they do. The more you work out and the more active you are the more you really could use things that help you to stoke up cellular energy.

So CoQ10  is very important and when it comes to muscles, and which muscle works the hardest?  Of course it's your heart! Your heart actually has more mitochondria than any other muscle tissue because of working so tirelessly. Every minute, hours a day, your heart is pumping and constricting and it needs that cellular energy. So CoQ10 is excellent to help your heart to maintain function.  It's good for your blood pressure. Many people have heart muscles that are actually in very good
shape especially the younger someone is the better shape that their muscles
are in. But, we know that there's a lot of young people that still have heart attacks and many times it's not because of the heart muscle itself so much as it is the pipes... the arteries that are leading into the heart like the coronary artery as well as other arteries that  feed the heart muscle that become clogged.

The oxygenation is cut off. If they get a clot the arteries can become completely obstructed and that's why heart attacks occur; the arteries become obstructed and then of course it affects the heart. It causes portions of the heart to go dead. That can be hard to reverse. But, again, for many people it's really the arteries that's the problem.

So CoQ10 is an excellent supplement for people with heart issues.


But, arginine even more so because of it being a precursor to nitric oxide. Nitric oxide is your body's best medicine to be able to keep your arteries healthy and in turn keeping your heart healthy.

Incidentally, amino acids like arginine also facilitate ATP production in the mitochondria as well so it has that benefit. But, let's go back to its benefits for nitric oxide. Your endothelium takes arginine that your body makes or that you get from your diet and supplementation and converts it into this gas called nitric oxide. Nitric oxide is responsible for opening your blood vessels and relaxing them and it helps to prevent plaque from starting in the first place.

The word picture that Dr. John Cooke used was that it keeps your arteries from becoming like Velcro and helping them to be more like Teflon where everything just slides through. So it helps prevent plaque from occurring, but also over time if there is plaque it actually helps the plaque to go away. I used to enjoy speaking with Dr. Prendergast and he talked about how you could reverse at least 10% of your plaque per year using arginine therapy or arginine supplementation.

So as far as your heart is concerned, long-term prevention, as well as a reversal of plaque in the arteries(which is the number one reason people have heart attacks), then arginine is in my opinion the most important thing for the heart.  Especially when you get past forty years of age.

If you want to supplement arginine along with a good ubiquinol or ubiquinone, 100 to 200 milligrams a day, that's an excellent thing. But, I would start with arginine. Dosage is important. At least 5000 milligrams per day along with high doses of citrulline to help for the turbo-charging and recycling effect of the arginine.

Arginine is where I would spend my money. In particular arginine based supplementation is necessary to elevate those nitric oxide levels that tend to decline after you hit age forty. You produce about 50% of the nitric oxide levels as compared to when you were twenty. That's why we see all these complications with heart attacks and strokes particularly after those years.

So I hope this helped as to which is best for your heart: COQ10 or arginine. I would start definitely with arginine supplementation to keep those arteries that lead to the heart nice and clean and then if you want to supplement with CoQ10 in addition, especially if you're on a statin medication, and since as we know that it robs your body of all CoQ10 and long-term very detrimental.

Dr. Sinatra mentions how this can lead to heart failure when you're on a long-term statin program. SoCoQ10 will be very invaluable at that point. Hopefully this helped to answer that question! Thanks for those good questions and keep them coming!

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Can Heart Disease Cause Depression?

Many diseases, such as heart disease and cardiovascular diseases come with feelings that can be classified as depression. If you have a bad flu, no doubt you will feel despondent, tired, and depressed. The same is true of hypothyroid disease, something that is often misdiagnosed as depression. Is it any wonder then that something as vital as your heart, if not working properly, could cause depression?

One popular dictionary defines depression as “feelings of severe despondency and dejection”.

Depression is now recognized as a risk factor for cardiovascular disease just like other illnesses and risk factors like diabetes, high blood pressure and smoking.

How are heart disease and depression linked?

One way is via stress. When under stress your body releases stress hormones like cortisol that can increase the risk of heart problems. Stress hormones are thought to be related to a host of mental health conditions including anxiety and depression. When not controlled correctly stress can lead to arterial damage, high blood pressure, irregular heartbeats as well as a weakened immune system.

The other more obvious way is simply systemic. If your heart is not working correctly, and your veins and arteries are damaged or full of plaque, you won’t feel good. Your body will suffer higher levels of inflammation. Hormones needed to repair your body won’t get to where they need to go as fast. Nutrients that need to be delivered to your cells will not be absorbed, all factors that will make you feel depressed!
Chicken or the Egg

Determining if you have depression and that is worsening a heart issue, or if you have a heart issue and that is making you feel depressed can be tricky!

Regardless of the origin, heart disease and depression can both be tackled physically and mentally.


If you have heart disease or cardiovascular issues there are two basic steps you can take to halt and even reverse the problem. The first step is to change your diet. With so many articles and information out there on this subject, it’s unnecessary and exhaustive to go into detail here. Search for heart-healthy diet options online and you will find plenty of information on the subject. Suffice to say, you need to change your diet by moving away from processed foods, and items high in bad types of fat.

The other physical component to healing heart disease and that also can help depression is supplementing with the amino acids L-Arginine and L-Citrulline. These two powerful healing amino acids when combined have been shown to reduce plaque build-up in the arteries and veins, reduce inflammation and help open your veins and arteries. They work by stimulating the production of Nitric Oxide, a substance that has been studied literally hundreds of thousands of times and shown to provide real results in study after study.

How they help the heart is rather straightforward. The removal of plaque and the healing of arteries clean out your cardiovascular system and help it heal. It makes the veins and arteries more elastic, returning them to a more youthful state. This helps reduce high blood pressure and can reverse the symptoms of cardiovascular disease.

How do arginine and citrulline help with depression?

If you have heart disease and your body is in a state of inflammation due to damaged arterial tissue and plaque build-up, it affects your entire body including your mind. A recent study found that even just having dry skin can cause so many inflammatory markers to be produced in the body, that it is now considered a major contributing factor for Alzheimer's Disease. If something on the outside of your body can cause brain issues, how much more so can something directly linked to your brain ( your circulatory system ) cause issues if it’s not healthy?

By helping to heal your circulatory system, you reduce inflammation and increase blood flow at the same time. So if your experiencing symptoms of depression caused by or related to heart disease, arginine and citrulline can be a major help.

How to Benefit from L-Arginine and L-Citrulline

To fully benefit from these beneficial amino acids, they must be taken in the right amounts and ratios. It also helps to take them with a mix of special antioxidants that boost their effect and duration.

Try M3 Ultimate Nitric Oxide Nutrition to boost overall blood pressure, circulation and heart health.