Types of Arginine

Types Of Arginine And Health Benefits

The Types Of Arginine are important to know because each type can offer slightly different benefits. Lets dive deeper and find out why.

L-Arginine plays a pivotal role in numerous physiological processes, offering various health benefits. It supports blood pressure, circulation, and offers many health benefits.

Its different forms cater to specific needs, so some enhance its overall effectiveness and some its bioavailability. Let’s delve into the details of each type and how they are made.

L-Arginine HCl (Hydrochloride)

L-Arginine HCl (Hydrochloride) is a variant of the amino acid L-Arginine. It is crucial for several bodily functions. The list is large, including protein synthesis, ammonia detoxification, and the production of nitric oxide. The key difference between L-Arginine HCl and regular L-Arginine lies in their composition and solubility.

Differences from Base Arginine

  • Composition: L-Arginine HCl combines L-Arginine with a hydrochloride molecule. This addition helps to stabilize the arginine, making it more palatable and increasing its solubility in water.
  • Solubility: The primary advantage of L-Arginine HCl over base arginine is its enhanced solubility. This feature makes it easier to consume in liquid form and potentially improves its absorption in the digestive system.
  • Taste: The hydrochloride form is generally considered to have a more tolerable taste comparing it to the base form, which is quite bitter.

Uses and Preferences

L-Arginine HCl is known for its various uses, particularly in areas related to cardiovascular health, athletic performance, and recovery from injuries or surgeries:

  • Cardiovascular Health: Due to its role in nitric oxide production, L-Arginine HCl is often used to support cardiovascular functions. This includes improving blood flow and reducing blood pressure.
  • Athletic Performance: Athletes may prefer L-Arginine HCl.  It has strong potential for improving blood flow and oxygen delivery to muscles during intense workouts. It is good for enhancing performance and recovery.
  • Wound Healing: Its ability to improve circulation also makes L-Arginine HCl a candidate for supporting faster wound healing.

Choosing L-Arginine HCl over Other Forms

The choice between L-Arginine HCl and other forms of L-Arginine often depends on the specific needs and preferences. Also important are potential sensitivities people may have:

  • Digestibility and Absorption: Those who might have sensitivity to the base form or require a more easily absorbed variant may opt for L-Arginine HCl due to its enhanced solubility.
  • Specific Health Goals: L-Arginine HCl might be preferred for cardiovascular support or to enhance exercise performance, where rapid absorption and efficacy are desired.
  • Taste Preferences: The less bitter taste of L-Arginine HCl can make it a more palatable option for individuals who struggle with the taste of base L-Arginine supplements.

In summary, while all forms of L-Arginine provide similar fundamental benefits due to their role in nitric oxide production and protein synthesis, the choice of L-Arginine HCl over others might be influenced by its solubility, absorption rate, taste, and specific health objectives. Always consulting with a healthcare provider before starting any new supplement regimen is advisable to ensure it aligns with your health needs and goals.

L-Arginine AKG (Alpha-Ketoglutarate)

Arginine AKG (Alpha-Ketoglutarate) combines the amino acid L-Arginine with Alpha-Ketoglutarate, a crucial molecule in the Krebs cycle, responsible for energy production. This blend offers unique benefits over base L-Arginine and other Arginine forms.

Differences from Base Arginine

  • Composition: The key difference lies in Alpha-Ketoglutarate’s addition to L-Arginine, enhancing the compound’s role in amino acid synthesis and energy generation.
  • Absorption and Effectiveness: The body absorbs and utilizes L-Arginine AKG more efficiently than base L-Arginine. Alpha-Ketoglutarate increases L-Arginine’s stability and bioavailability.
  • Energy Production: L-Arginine AKG’s involvement in the Krebs cycle makes it highly effective in boosting energy, offering significant benefits for energy-demanding activities.

Uses and Preferences

L-Arginine AKG is particularly popular for specific uses, mainly in the realms of athletic performance and recovery:

  • Enhanced Athletic Performance: Athletes and bodybuilders often choose L-Arginine AKG for its superior ability to boost nitric oxide production, enhancing blood flow, oxygen delivery to muscles, and overall performance.
  • Supports Muscle Recovery: The compound aids in quicker muscle recovery post-intense workouts by improving nutrient delivery to muscles.
  • Energy Boost: People looking for an energy increase during physical activities benefit from L-Arginine AKG, thanks to its critical role in the energy production cycle.

Choosing L-Arginine AKG over Other Forms

Choosing L-Arginine AKG over other Arginine forms usually aligns with specific goals, especially concerning physical performance and energy needs:

  • For Athletic Performance and Recovery: Individuals aiming to maximize physical performance and enhance muscle recovery might find L-Arginine AKG more suitable due to its nitric oxide production and absorption benefits.
  • For Energy Enhancement: Those in need of an energy uplift for workouts or athletic endeavors may prefer L-Arginine AKG for its direct involvement in energy production.

L-Arginine Aspartate

Arginine Aspartate stands out from L-Arginine AKG and base L-Arginine due to its unique combination and specific applications:

Unique Characteristics of L-Arginine Aspartate

  • Aspartate Component: Unlike AKG, which is involved in the Krebs cycle and energy production, aspartate plays a critical role in the urea cycle. It is adept at helping to eliminate excess nitrogen from the body. This function of aspartate can enhance endurance by efficiently removing ammonia. Ammonia is a byproduct of exercising muscle, thus potentially reducing fatigue.
  • Neurotransmitter Support: Aspartic acid acts as a neurotransmitter in the brain. This can influence the production of testosterone, enhancing hormone levels that are crucial for muscle mass and strength. This aspect differentiates it from L-Arginine AKG, which does not directly influence neurotransmitter levels or hormone production.
  • Enhanced Endurance and Recovery: Both AKG and aspartate forms are known for their potential to enhance athletic performance,. L-Arginine Aspartate however, specifically offers benefits related to endurance and recovery. This is due to its role in ammonia detoxification.

Applications and When to Use L-Arginine Aspartate

  • For Enhanced Endurance Sports Performance: Due to its efficient role in ammonia detoxification, individuals engaged in endurance sports might prefer L-Arginine Aspartate to support longer periods of physical activity and to reduce recovery time.
  • When Seeking Hormonal Support: Those looking into natural ways to support hormone production, particularly testosterone, might find L-Arginine Aspartate beneficial due to the neurotransmitter role of aspartic acid.
  • For Comprehensive Athletic Support: Athletes focusing on both performance and recovery, especially in sports that demand high endurance, might choose L-Arginine Aspartate over AKG or base L-Arginine for its dual action in energy metabolism and detoxification.

In contrast to L-Arginine AKG, which is often chosen for its direct benefits on energy production and nitric oxide synthesis, L-Arginine Aspartate offers a broader spectrum of support, particularly beneficial for endurance and recovery, making it a distinct choice for athletes and individuals seeking specific health benefits.

L-Arginine Malate

Arginine Malate is a compound that combines L-Arginine with Malate, a tricarboxylic acid cycle (TCA cycle or Krebs cycle) intermediate. This combination offers distinct advantages and uses compared to other forms of L-Arginine.

Differences and Unique Benefits of L-Arginine Malate

  • Enhanced Energy Production: Malate plays a crucial role in the Krebs cycle, a key energy-producing process in the body. L-Arginine Malate, therefore, not only boosts nitric oxide levels but also supports energy production at a cellular level. Therefore making it particularly beneficial for endurance and performance.
  • Improved Athletic Performance: Due to its dual role in enhancing nitric oxide production and supporting the Krebs cycle, L-Arginine Malate is often chosen by athletes. They choose it seeking to improve their performance, endurance, and recovery times.
  • Support for Aerobic and Anaerobic Metabolism: The presence of Malate supports both aerobic (with oxygen) and anaerobic (without oxygen) energy pathways, offering a versatile energy boost that can be beneficial across different types of physical activities.

Contrast with Other Forms of L-Arginine

  • L-Arginine HCl: While L-Arginine HCl is primarily sought after for its improved solubility and absorption, L-Arginine Malate offers the added benefit of supporting energy production, making it a more suitable choice for individuals looking to enhance physical performance and energy levels.
  • L-Arginine AKG: Although L-Arginine AKG is also known for its role in energy production and nitric oxide synthesis, L-Arginine Malate might be preferred for activities that require sustained energy over longer periods, due to the efficient role of Malate in the Krebs cycle.
  • Base L-Arginine: The base form of L-Arginine primarily serves to increase nitric oxide production. However, L-Arginine Malate extends beyond this by also enhancing energy production, offering a broader range of benefits for physical activity and performance.

When to Use L-Arginine Malate

  • Endurance Athletes: Individuals engaged in long-duration sports or activities may find L-Arginine Malate particularly beneficial for its dual role in boosting nitric oxide levels and supporting sustained energy production.
  • Those Seeking Enhanced Recovery: The improved blood flow from increased nitric oxide production, combined with efficient energy metabolism, can help facilitate quicker recovery after intense workouts.
  • Individuals Focused on Aerobic and Anaerobic Performance: L-Arginine Malate’s support for both energy pathways makes it an excellent choice for athletes who engage in a mix of aerobic and anaerobic exercises.

In summary, L-Arginine Malate offers unique benefits that make it stand out from other forms of L-Arginine, especially for athletes and individuals seeking to improve their energy levels, performance, and recovery. Its ability to support nitric oxide production and energy metabolism simultaneously provides a comprehensive approach to enhancing physical performance.

 

In essence, L-Arginine AKG stands out for individuals focused on sports performance. It’s great for recovery, and energy thanks to its enhanced bioavailability and contribution to energy metabolism.  Each of these forms of L-Arginine is designed to optimize the amino acid’s benefits. Whether used for improving cardiovascular health, enhancing athletic performance, or supporting overall well-being. The choice of form can depend on the desired effect, the method of delivery, and individual tolerance.


Stop Taking Arginine

Top 5 Reasons to Stop Taking Arginine Alone

Stop Taking Arginine you say? Is there a reason you should stop or is there simply a better way to take it? Lets see!

Scientists discovered arginine, an amino acid, in the late 19th century. Its use has surged in popularity over the years as a coveted supplement among athletes and fitness enthusiasts. It is also popular amoung those seeking to improve their cardiovascular health. Also, it can support lower blood pressure and offers support for those seeking cognitive improvements.

What Is Arginine?

This semi-essential amino acid plays a pivotal role in synthesizing proteins and supporting nitric oxide production in the body. It also enhances blood flow and nutrient delivery to muscle tissues. Its reputation for boosting exercise performance, aiding in recovery, and offering cardiovascular benefits is well know. This reputation has cemented arginine’s place on the shelves of health stores and in the regimens of health-conscious individuals worldwide. But does it work? Should you stop taking arginine?

The burgeoning interest in arginine has also ushered in a wave of scrutiny and research aimed at understanding its efficacy.

Arginine’s Benefits

Arginine’s benefits are not in dispute. Emerging evidence, however, suggests that its effectiveness can be significantly amplified when combined with other nutrients. So and we aim to show why your should stop taking arginine alone. This article aims to shed light on the limitations of solo arginine supplementation. We strongly advocate for its combination with other nutrients because of improved health outcomes.

One of the primary reasons behind the push for combining arginine with other ingredients lies in its bioavailability. The body’s ability to utilize it effectively is a common concern. It also has a powerful effect of other substances such as NOS ( Nitric Oxide Synthase). When taken alone, the absorption of arginine can encounter physiological barriers that limit its effectiveness, absorption and lifespan.

Other Amino Acids

The presence of other amino acids can compete with arginine for absorption in the gut. This reduces the amount that ultimately enters the bloodstream and reaches the tissues where it is most needed. However, some amino acids have the opposite effect and can boost its effect! Just this alone is a great justification for why you should stop taking arginine alone!

This competition from the wrong kinds of amino acids can diminish the perceived benefits of arginine. This is particularly so in the realms of exercise performance and cardiovascular health.

Better Blood Vessel Dilation

Arginine’s role in the production of nitric oxide has been well-documented. This is because the conversion of arginine into nitric oxide can be inefficient without other complementary nutrients. This inefficiency highlights another limitation of relying solely on arginine. To achieve desired health outcomes, such as improved blood flow and improved exercise capacity, more is needed.

The case for combining arginine with other nutrients also extends to its synergistic interactions with certain vitamins and minerals. For example, vitamin D has been shown to work in tandem with arginine to bolster the immune system. It also plays a role in helping to support bone health. Antioxidants like vitamins E and C can enhance arginine’s cardiovascular benefits by reducing stress and inflammation. These interactions underscore the multifaceted nature of nutrition and wellness. This is because the combined effect of different nutrients often surpasses the sum of their individual benefits.

Arginine As A Supplement

The purpose of this article is not to diminish the value of arginine as a supplement. We aim  to illuminate a more nature based approach to its use. By combining arginine with complementary nutrients such as citrulline, vitamin D, horse chestnut, and vitamins E and C, individuals can potentially unlock a broader spectrum of health benefits and achieve more pronounced improvements in cardiovascular health, exercise performance, and overall well-being.

As we delve deeper into the limitations of solo arginine supplementation it becomes clear that the path to optimal health is not through isolated ingredients. We see it is through a well-rounded and informed approach to nutrition. This perspective enriches our understanding of how different nutrients interact. It also empowers us to make more effective decisions about our health and wellness strategies.

Reason 1: Limited Absorption and Bioavailability

Arginine, when consumed as a standalone supplement, faces significant challenges related to its absorption and bioavailability in the human body. This amino acid competes with other amino acids for transporters in the gut and bloodstream. This competition can significantly reduce the amount of arginine that is effectively absorbed and utilized by the body. Yet another reason why you should stop taking arginine alone.

Absorption

The presence of other amino acids in the digestive system can inhibit arginine’s entry into the bloodstream. This sometimes diminishes its overall effectiveness, making it a waste of time and money to consume.

The bioavailability of arginine is not just about how much is absorbed. How efficiently it is used by the body is also important. This is because once absorbed, arginine serves as a precursor for the synthesis of nitric oxide (NO). As mentioned before NO a critical molecule for cardiovascular health, immune function, and wound healing.

The conversion rate of arginine to nitric oxide can be lowered or just plan stopped in the absence of complementary nutrients. This leads to less than ideal health outcomes. So to summarize, add the wrong things and arginine may not work. Add the right things and you can put it in overdrive!

Combinations That Count: Stop Taking Arginine By Itself

The issue of limited absorption and bioavailability underscores the importance of not just consuming arginine but ensuring it is taken correctly. This can be improved by combining arginine with other things that enhance its absorption or work together to bolster its effects.

For instance, pairing arginine with citrulline, another amino acid, has been shown to enhance the overall bioavailability of arginine, see chart below for more info.

Citrulline is converted into arginine in the kidney, which not only increases the plasma levels of arginine but also prolongs its availability for nitric oxide production, thereby amplifying the cardiovascular benefits.

Summary of Reason #1

So in summary, while arginine alone possesses undeniable health benefits, its limited absorption and bioavailability can hinder its effectiveness. There are great reasons why you may want to stop taking arginine alone. By understanding and addressing these limitations through strategic supplementation, individuals can better harness arginine’s potential health benefits. This approach not only optimizes the intake of arginine but also underscores a broader principle. That being; nutritional supplementation often yields the best results when approached naturally.

stop taking arginine chart

Stop Taking Arginine Alone

  • Vitamin C: Enhances nitric oxide production from Arginine by stabilizing it and reducing its breakdown.
  • Vitamin D3: Works synergistically to support cardiovascular health and may enhance the effectiveness of Arginine. Vitamin D also helps your body produce more NOS.
  • Vitamin E: Protects cells from cellular stress, potentially enhancing Arginine’s effects on vascular health.
  • Vitamin K2 (MK-7): May work with Arginine to support arterial health and flexibility.
  • L-Citrulline: Converts to Arginine in the body, increasing Arginine levels and nitric oxide production.
  • Pomegranate, Watermelon, Blackberry, Raspberry: These fruits are rich in antioxidants and other compounds that can support nitric oxide production and enhance the effects of Arginine.
  • Hawthorn Berry, Horse Chestnut: Known for their vascular health benefits, potentially complementing Arginine’s cardiovascular effects.
  • Green Coffee Extract, Indian Gooseberry, Grape Seed Skin Extract, Camu Camu Berry: These ingredients offer antioxidant support, which can synergize with Arginine’s health benefits.
  • Deep Ocean Minerals: May provide trace minerals that support overall metabolic processes, including those involving Arginine.
  • AstraGin: Known to enhance nutrient absorption, potentially improving Arginine bioavailability.
  • Organic Inulin: A prebiotic fiber that can support gut health, possibly affecting Arginine’s absorption positively.

Cardiovascular Health

Arginine is well-known for its critical role in the production of nitric oxide (NO). NO is  a vital molecule that influences various aspects of cardiovascular health as we have discussed above.

Nitric oxide acts as a vasodilator, meaning it relaxes the inner muscles of blood vessels. This causes them to widen and thereby improve blood flow and energy, etc.

This effect can lower blood pressure, enhance exercise performance, and reduce the risk of cardiovascular diseases. It even helps with some cognitive issues and diseases of the eye as well.

Despite its potential, the production of nitric oxide from arginine can be hampered when arginine is consumed alone. This is due to factors like enzyme availability, oxidative stress, and the presence of asymmetric dimethylarginine (ADMA). ADMA is a natural inhibitor of nitric oxide synthesis. In other words, if you stop taking arginine by itself, you get more of it. The results are better if your taking it with the right things.

Citrulline

The combination of arginine with citrulline is a strategy that can overcome these limitations. Combining the two can lead to more efficient nitric oxide production. This is yet another reason why you may want to top taking arginine alone. Citrulline is converted into arginine in the kidneys. It increases the plasma levels of arginine and also provides a more sustained release of arginine for nitric oxide production. Combining bypasses the competitive absorption issues in the gut. It also helps maintain higher levels of nitric oxide in the bloodstream. Combining the two enhanci cardiovascular benefits such as improved vascular tone, blood flow, and reduced blood pressure.

Vitamins E, C, and K2

These play supportive roles in enhancing nitric oxide production and ensuring its stability:

Vitamin E

This antioxidant helps protect nitric oxide from  degradation via oxidatiion that can rapidly neutralize nitric oxide. It reduces the availability and effectiveness of NO in vasodilation. By reducing oxidative stress, vitamin E preserves nitric oxide levels. More NO means more cardiovascular benefits.

Vitamin Cnews.bionoxusa.com/heart-healthy-meal-prep

Similar to vitamin E, vitamin C is an antioxidant that can synergize with arginine by stabilizing nitric oxide. Vitamin C reduces its breakdown in the bloodstream. C has also been shown to regenerate vitamin E, thus working together. These vitamins create a powerful antioxidant network that protects nitric oxide and enhances its effects on blood vessel dilation.

Vitamin K2 (MK-7)

While its role in nitric oxide production may not be as apparent as other vitamins, vitamin K2 contributes to cardiovascular health. It does so by preventing calcium deposition in the arteries. This action helps maintain arterial flexibility and function. There is emerging evidence that vitamin K2 may also support the endothelial function. This is is crucial for nitric oxide production and regulation. By promoting overall vascular health, vitamin K2 can indirectly support the optimal function of nitric oxide.

So, while arginine is a key precursor to nitric oxide its solo use can result in poor nitric oxide production. This is due to various physiological constraints, making it kind of a waste of money to take alone.

Combining arginine with citrulline and other vitamins can significantly enhance the production of nitric oxide. This strategic supplementation approach not only amplifies the cardiovascular benefits. It also supports broader health outcomes and benefits. This is done by ensuring efficient blood flow and nutrient delivery throughout the body and therefore more nitric oxide.

Reason 3: Inadequate Support for Vascular Health

Vascular health is fundamental to the overall well-being of the cardiovascular system, brain, gut, you name it. Healthy blood vessels are essential for the efficient transport of oxygen and nutrients to every part of the body. They also are vital for the removal of waste products, energy, vitality and pretty much everything.

Good vascular health also plays a critical role in preventing conditions such as atherosclerosis, hypertension, and PAD to name a few. While arginine is renowned for its capacity to enhance nitric oxide production and thus improve vasodilation and blood flow, relying on arginine alone might not offer comprehensive support for vascular health. This is because vascular health encompasses more than just the ability of blood vessels to dilate; it also includes the strength, elasticity, and integrity of the blood vessel walls.

Horse Chestnut

Enter the synergistic potential of combining arginine with horse chestnut (Aesculus hippocastanum), an herbal supplement known for its heart healthy properties. Horse chestnut can significantly enhance heart health. This amazing plant contains a compound called aescin. The active ingredients in aescin have been shown to strengthen capillary walls, reduce inflammation, and improve blood vessel tone. This can be particularly beneficial in conditions such as chronic venous insufficiency, where veins struggle to return blood to the heart efficiently.

Horse Chestnut

The combination of arginine and horse chestnut works on multiple fronts to support vascular health. This is because of arginine’s role in nitric oxide production addresses the need for vasodilation and improved blood flow.  Horse chestnut’s heart healthy and anti-inflammatory effects contribute to the structural health and functionality of the blood vessels.

Dual Action

This dual-action approach ensures that blood vessels are not only capable of adjusting their diameter for optimal blood flow but are also strong, resilient, and less prone to damage and inflammation.

Furthermore, the antioxidant properties of horse chestnut complement arginine’s cardiovascular benefits by protecting the endothelial cells lining the blood vessels. This protection can lead to stopping endothelial dysfunction, a precursor to atherosclerosis and other circulatory diseases. By stopping oxidative damage, the combination of arginine and horse chestnut supports the integrity of the inner veins, enhancing its capacity to produce nitric oxide and maintain vascular health.

In summary, while arginine alone offers significant benefits for enhancing nitric oxide production and improving vasodilation, it may not provide complete support for the multifaceted aspects of vascular health. Incorporating horse chestnut into a supplementation regimen that includes arginine can offer a more basic approach to maintaining and improving vascular health. This combination not only optimizes blood flow but also addresses the structural and functional needs of blood vessels, offering a comprehensive strategy for cardiovascular wellness.

Reason 4: Better Nitric Oxide Production with Vitamin D Supplementation: Stop Taking Arginine Alone

Vitamin D’s relationship with arginine extends beyond basic nutritional synergy, directly impacting the efficiency of nitric oxide (NO) synthesis and the activity of nitric oxide synthase (NOS), the enzyme responsible for NO production from arginine. This interaction is crucial for understanding how the combination of arginine and vitamin D can significantly amplify and promote cardiovascular health, immune function, and overall well-being.

Vitamin D has been shown to enhance the expression and activity of nitric oxide synthase, thereby increasing the conversion of arginine into nitric oxide and this increase in nitric oxide availability is vital for vasodilation, which improves blood flow and reduces blood pressure, supporting your heart.

More NO

The enhancement of NO production by vitamin D not only increases the heart health benefits provided by arginine but also supports the function of the inner lining of blood vessels, further protecting against arterial stiffness and cardiovascular disease.

The synergy between vitamin D and arginine in creating higher nitric oxide levels has broader health implications as well, especially for your immune system and bone health. Elevated NO levels can improve immune response by supporting the body’s defense mechanisms against diseases. Nitric oxide acts as a signaling molecule in the immune system, managing various processes involved in the immune response. Vitamin D, well-recognized for its role in supporting immune function and reducing inflammation, works in concert with arginine-derived NO to create a more effective immune response.

In terms of bone health, the improved blood flow resulting from increased nitric oxide production ensures that nutrients essential for bone maintenance, including calcium and phosphate, are efficiently delivered and utilized in the body.

Calcium Absorption

Vitamin D plays a direct role in calcium absorption and bone mineralization, making its combination with arginine a strategic approach to supporting skeletal health and heart health.

Arguing for the effectiveness of taking arginine with vitamin D rests on understanding these mechanisms as well as vitamin D’s ability to increase nitric oxide synthase and increase nitric oxide production from arginine. This provides a compelling reason to combine Vit D for improved health outcomes. This synergy not only enhances cardiovascular benefits by improving vascular function and reducing blood pressure but also supports robust immune function and contributes to the maintenance of healthy bones.

The combination of arginine and vitamin D offers a potent approach to health supplementation, with vitamin D significantly enhancing the conversion of arginine into nitric oxide and thereby amplifying the benefits of arginine supplementation. This partnership between vitamin D and arginine underscores the importance of a natural approach to supplementation, where the combined effects of nutrients are leveraged to achieve the best health outcomes.

Reason 5: Reduced Antioxidant Protection

Antioxidants play a pivotal role in safeguarding the body against oxidation, a condition characterized by an imbalance between free radicals and antioxidants. Free radicals are unstable molecules that can damage your cells, contributing to aging and various diseases, including cardiovascular disease, diabetes, and cancer, obviously things no one wants!

Antioxidants neutralize these nasty free radicals, thus protecting the body from damage. While arginine is known for its cardiovascular and immune system benefits, its antioxidant potential can be significantly improved when combined with vitamins E and C, both of which are powerful antioxidants. Also antioxidants make the nitric oxide molecule last longer, so they boost nitric oxides lifespan, and therefore effect! Yet another good reason you want to stop taking arginine by itself!

Vitamin E

Vitamin E is a fat-soluble antioxidant that protects cell membranes from cellular damage by reacting with free radicals, which prevents the propagation of free radical damage within the body. This vitamin is particularly effective in protecting against lipid peroxidation, a process that can compromise cell membrane integrity and function. By maintaining cell membrane health, vitamin E supports the optimal functioning of cells, including those involved in the synthesis and utilization of arginine.

Vitamin C, a water-soluble antioxidant, complements vitamin E by neutralizing free radicals in the aqueous environments of the body. Furthermore, vitamin C can regenerate oxidized vitamin E, thereby restoring its antioxidant capacity making this a synergistic interaction that enhances the body’s overall antioxidant defense system.

Vitamin C

Vitamin C also plays a crucial role in the synthesis of collagen, a protein essential for the maintenance of blood vessels, skin, and connective tissues. The presence of adequate vitamin C can thus support the structural health of blood vessels, ensuring a conducive environment for arginine’s cardiovascular benefits.

The combination of arginine with vitamins E and C offers a multi-faceted approach to combating oxidative stress and supporting your health. Arginine, through its role in nitric oxide production, can improve vascular health and support the delivery of nutrients, including antioxidants, to tissues throughout the body while, vitamins E and C directly neutralize free radicals and protect against cellular damage. This collective action increases the antioxidant potential of these nutrients and also enhances their individual benefits. These benefits being mostly related to cardiovascular health, immune function, and tissue repair.

Advocating for the combination of arginine with vitamins E and C is grounded in the understanding that optimal personal health outcomes are often achieved through synergistic nutritional strategies.

This approach leverages the complementary actions of arginine and antioxidants to fortify the body’s defenses against disease, thereby supporting overall health and well-being.

By incorporating these nutrients into a comprehensive supplementation regimen, you can harness a more potent antioxidant defense, offering broader protection against damage and its associated health risks.

Health

Stop Taking Arginine

arginine nitric oxide

Debunking the Myth: Does L-Arginine Work?

Does L-Arginine Work?

In the world of health supplements and nitric oxide products, few amino acids have garnered as much attention as L-Arginine, particularly for its role in producing nitric oxide (NO), a molecule vital for vascular health.

However, as with many popular supplements, L-Arginine has seen its fair share of detractors. Some companies, possibly driven by motives to promote their own products or strategies, claim that L-Arginine does not work. Let’s dive into these assertions, understand their basis, and examine the broader picture.

Does L-Arginine Work? Why Do Some Claim L-Arginine Doesn’t Work?

  1. Selective Interpretation of Research: Some of the most vocal criticisms stem from some studies suggesting that L-Arginine supplementation may not always result in improved NO production, especially in those with compromised endothelial function. These very limited studies sometimes conclude that the Nitric Oxide Synthase (NOS) enzyme, responsible for converting L-Arginine to NO, might not operate efficiently in everyone. It is important to keep in mind there are almost 100,000 studies showing arginine roles in promoting health and supporting nitric oxide. Yet only a handful of studies show no effects or negative effects.
  2. Marketing Motives: It’s no secret that the health industry is competitive. Companies vying for a larger market share of the NO-boosting segment might downplay the benefits of L-Arginine to promote alternative products, like beetroot extracts. Everyone is looking for a unique angle and message; the goal is to sell you their unique product.
  3. Misunderstanding of Mechanisms: The process of NO production is complex. It’s not just about consuming L-Arginine; other factors like oxidative stress, the presence of heavy metals, and overall health can impact the efficiency of the NOS enzyme.

Why L-Arginine DOES Work: Looking Beyond the Myths

  1. Overwhelming Positive Research: While there are a few studies pointing to the limitations of L-Arginine, there are thousands more that highlight its benefits. A vast body of research has showcased the efficacy of L-Arginine in boosting nitric oxide levels, supporting cardiovascular health, aiding muscle growth, and so much more!
  2. Understanding the Body’s Complexity: The body is not a one-size-fits-all mechanism. Just because L-Arginine might not work for a specific subset of people under particular conditions does not render it ineffective for everyone. Individual biochemistry, diet, lifestyle, and even genetics can influence how one responds to L-Arginine supplementation.
  3. Supporting Ingredients and Strategies: Often, the effectiveness of L-Arginine can be enhanced when combined with other supporting ingredients. For instance, antioxidants can mitigate oxidative stress, improving the environment in which the NOS enzyme functions. Similarly, detoxification agents can remove heavy metals that might hinder NO production. Vitamin D plays a huge role in nitric oxide production as well.

Understanding the NOS Pathway and the Logic of Detoxification Over Beet Supplementation

The Nitric Oxide Synthase (NOS) pathway is crucial in nitric oxide (NO) production. As we age, it’s believed, as mentioned above, that the efficiency of the NOS pathway diminishes, potentially leading to a reduction in NO production. In light of this fact for many, two primary strategies are often proposed: direct nitrate supplementation through beetroot products and detoxification of the NOS pathway.

Let’s explore why detoxifying the NOS pathway might be a more logical approach and why fixing the problem is better than just using what works under a broken system.

1. Addressing the Root Cause vs. Symptom Treatment:

  • Beetroot Approach: Beets are veggies that are rich in dietary nitrates, which the body can convert into nitric oxide through a different pathway, bypassing the NOS enzyme. This is a direct supplementation approach. While it can raise NO levels, it does not address the inherent dysfunction within the NOS pathway. Thus, the root cause of the diminished NO production due to a compromised NOS pathway remains unaddressed.
  • Detoxification Approach: By focusing on detoxifying the NOS pathway, you can restore its original function. Over time, various factors such as oxidative stress, accumulation of heavy metals, and other toxins can impair the NOS pathway. Detoxifying can potentially remove these hindrances, allowing the NOS enzyme to function optimally. Why not restore your body’s ability to convert arginine into nitric oxide? It makes so much more sense to treat the entire system and not just bypass it.

2. Comprehensive Health Benefits of Detoxification:

Beyond just improving the NOS pathway, detoxification offers many health benefits. It can lead to increased energy, improved cognitive function, reduced risk of chronic diseases, and an immune system boost. In contrast, while beet supplementation boosts NO levels, it might not offer these broader health benefits associated with detoxification.

3. Variability in Response to Beets:

Not everyone may benefit equally from beet supplementation. Factors such as gut flora composition and oral hygiene can influence the conversion of dietary nitrates from beets to NO. On the other hand, detoxifying the NOS pathway could possibly provide more consistent benefits across different types of individuals, as the emphasis is on enhancing a natural physiological process.

4. Long-Term Sustainability:

Detoxification can lead to sustainable improvements in the NOS pathway, potentially providing you with longer-lasting benefits. Conversely, the effects of beet supplementation are often transient in nature. Once supplementation stops, the boosted NO levels might decline, especially if a person’s NOS pathway remains compromised.

 

In Conclusion

Does L-Arginine Work? Yes, it certainly does and has been shown to work repeatedly in study after study. While beetroot supplementation can certainly be a part of your personal strategy to boost your nitric oxide levels, especially if you have significant NOS impairment, it’s essential to recognize the potential limitations of beetroot and nitrates. Detoxifying and revitalizing the NOS pathway addresses the issue at its core, aiming to restore the body’s natural ability to produce nitric oxide. This holistic approach boosts NO levels and improves overall well-being and long-term health.


Zeolite Supplements

Zeolite Supplements

Zeolite Supplements – An Unparalleled Detox Experience

Zeolite has always been a subject of intrigue and study, from ancient Rome’s aqueducts to modern wellness enthusiasts.

Because of its unique molecular structure, this natural wonder promises a range of health benefits that few supplements can match.

Zeolite Through the Ages

Zeolite’s journey began centuries ago, with ancient civilizations holding it in high regard not just for its health benefits but also because of its reactions to heat and common use in water purification. Over the millennia, as our understanding deepened, Zeolite made the transition from construction sites to health stores.

Historically, the Romans are celebrated for their advanced engineering, especially in the construction of aqueducts and other infrastructural works. They utilized these naturally occurring, porous minerals, zeolites, primarily for water purification. Zeolites can exchange certain positively charged ions (cations) thanks to their microporous structures. This ion exchange capability allowed them to soften water.

More specifically, the Romans purified their water using a type of zeolite called “chabazite.” They incorporated this mineral into their aqueduct systems, where the passing water exchanged its calcium for sodium in the zeolite, softening the water. This process was particularly beneficial in preventing calcium buildup in their complex aqueduct systems. The advanced nature of their practices is remarkable.

The Science Behind the Magic

Beneath its gritty exterior, Zeolite boasts a lattice-like structure. Because of this, it has an uncanny ability to trap and eliminate unwanted substances. Thus explaining its growing popularity as a detoxifying agent.

Some studies suggest that it might even have antibacterial properties due to its high cation exchange capacity, which can affect the environment where bacteria live, making it less conducive for their growth.

Why Zeolite Supplements?

Toxin Terminator

Zeolites have a keen sense for toxins. This is because they bind, trap, and aid in expelling them from our system.

Antioxidant Boost

With the world becoming an oxidative battleground, Zeolite is a sentinel, combating oxidative stress.

Balancing Act

Our body’s pH swings with our diet and stress. Zeolites help restore the balance, promoting an alkaline environment.

Precautions and Pairings

Kidney ailments? Approach Zeolite with caution.  If you are considering taking a zeolite supplement, especially with kidney issues, you must be aware of its effects and any potential interactions with other ingredients.

Zeolites are renowned for their ability to adsorb. They are know for trapping and removing various substances. There are many substances,  including heavy metals and toxins, that it can remove from the body. The adsorption process binds these substances to the zeolite particles. After binding, the body needs to eliminate these substances, a role the kidneys play.

The potential concerns related to kidney function when taking zeolite include:

  1. Increased Load on Kidneys: As zeolite binds to toxins and heavy metals, the kidneys work to filter and excrete these compounds. An increased load of these bound materials may add extra stress to the kidneys, especially if taken in large amounts or over extended periods.
  2. Reabsorption: There’s a possibility that not all bound toxins will be excreted efficiently. Some might be reabsorbed into the bloodstream, causing the kidneys to work harder to remove them a second time.
  3. Crystalline Structure: Some believe that the crystalline structure of zeolites could potentially cause harm if the particles are not small enough. Larger particles might not be easily processed and excreted by the kidneys, though most commercially available zeolite supplements are micronized or broken down to ensure safe passage through the body.
  4. Mineral Imbalance: Zeolites don’t just bind to “bad” substances. They can also bind to essential minerals, potentially leading to mineral imbalances. If important minerals like potassium or magnesium are depleted, it can affect kidney function.
  5. Potential Contamination: Natural zeolites can sometimes contain other metals or compounds. If not properly processed and purified, these contaminants might introduce additional substances for the kidneys to filter.

Considering the above possible issues, we developed Chelanox to provide a gentle flushing of the kidneys and a potent dose of Zeolite. Chelanox by Bionox contains not just zeolite, but a blend of other ingredients, some of which may benefit the kidneys, making it safe to take with Zeolite.

Breakdown Of Ingredients

  1. EDTA (Calcium Disodium): Often used in chelation therapy and for detoxing. EDTA helps bind heavy metals in the bloodstream, preparing them for excretion via the urine. Removing these toxins gives the kidneys potential relief, as they won’t need to filter these harmful substances.
  2. Chlorella Algae: Chlorella shows detoxifying properties, helping to remove heavy metals and other toxins from the body. This might support kidney function by reducing the toxins the kidneys have to handle.
  3. Uva Ursi Leaf Powder: Traditionally, Uva Ursi has been used as a natural remedy for urinary tract infections. It possesses diuretic properties, which may help cleanse the kidneys and urinary system.
  4. Milk Thistle Seed Powder: Milk thistle supports liver function, which in turn can aid the kidneys. When the liver functions optimally, it processes toxins more effectively, so fewer toxins reach the kidneys.
  5. NAC (N-Acetyl Cysteine): An antioxidant that can help replenish intracellular levels of the natural antioxidant glutathione. Glutathione assists in detoxification processes, potentially reducing the strain on the kidneys.
  6. Alpha Lipoic Acid: This is both water- and fat-soluble, meaning it can work throughout the body. It helps with heavy metal detoxification and supports both liver and kidney function.

By providing a combination of ingredients that support detoxification processes and the health of the liver and kidneys, Chelanox aims to balance the potent adsorption qualities of zeolite. However, it’s vital that anyone, especially those with kidney concerns, consults with a healthcare professional before starting any new supplement like Chelanox.

Chelanox: Zeolite’s Perfect Partner

While Zeolite is impressive on its own, synergy with products like Chelanox elevates its potency. Consider Chelanox as Zeolite 2.0 – enhanced with EDTA, Chlorella, and Cilantro extract. This alliance fortifies detoxification, paving the way for a more robust immune system and a healthier heart. It works amazingly well in combination with Nitric Oxide Products.

Nitric Oxide & Zeolite

From the depths of the earth, zeolite supplements emerge as a beacon for those in pursuit of detoxification. Their combination with products like Chelanox enhances these detox benefits. Yet, their impact extends beyond detoxification to include another critical element: Nitric Oxide (NO).

Nitric Oxide plays a crucial role in supporting various vital body functions. These include vasodilation (the expansion of blood vessels), blood pressure regulation, circulation improvement, and the modulation of immune responses. Produced through the Nitric Oxide Synthase (NOS) pathway, NO is akin to the circulatory system, but for distributing nitric oxide instead of blood. However, this pathway can be hindered by toxins and heavy metals, affecting NO production.

Here’s how Chelanox with Zeolite, when taken in conjunction with a nitric oxide supplement, can be a powerful combination:

  1. Detoxification of the NOS Pathway: Heavy metals and other toxins can negatively affect the NOS pathway. For instance, heavy metals like lead, cadmium, and mercury can disrupt enzymatic activities essential for producing nitric oxide. Chelanox, with its blend of detoxifying ingredients like EDTA, chlorella, and cilantro extract, can help chelate and remove these heavy metals. This assures that the NOS pathway functions optimally.
  2. Enhancing Blood Flow: The primary function of nitric oxide is to promote vasodilation and blood flow. The NOS pathway operates efficiently, ensuring it keeps heavy metals and toxins at bay. By using Chelanox with Zeolite, you support better blood flow and improved delivery of nutrients so oxygen gets delivered to more tissues.
  3. Improving Nutrient Absorption: Chelanox plays a vital role in gut health and overall digestive function. It does so by chelating and removing toxins and heavy metals from the body. This can lead to better absorption of essential nutrients, including those from nitric oxide supplements.
  4. Supporting Kidney Function: The kidneys must carefully process zeolites, an ingredient in Chelanox, as previously mentioned. Ingredients in Chelanox, such as milk thistle, play a crucial role in supporting liver function. This support indirectly benefits kidney health. Proper kidney function ensures improved blood pressure regulation, because of the enhancing effects of nitric oxide.
  5. Synergistic Immune Support: While nitric oxide plays a role in immune modulation, toxins, and heavy metals can impede the immune system. By detoxifying the body using Chelanox, the immune system can operate more effectively. It helps by synergistically working with nitric oxide to combat pathogens and inflammation.
  6. Optimized Cardiovascular Health: One of the major benefits of nitric oxide is its positive effect on cardiovascular health. Chelanox removes heavy metal impediments. This allows the heart and vascular system to benefit. Nitric oxide supplementation then improves cardiovascular function.

Combining Chelanox with a nitric oxide supplement ensures better health. It helps detoxifying the body and optimizes the pathways and systems that nitric oxide uses. By keeping the NOS pathway clear of impediments, the body can effectively utilize nitric oxide for various benefits, from improved circulation to enhanced immune function.


Hiking and Nitric Oxide

Hiking is one of the most enjoyable and rewarding outdoor activities that people of all ages can participate in. Whether you are a seasoned hiker or a beginner, there is something magical about exploring new trails, taking in the beauty of nature, and challenging yourself physically and mentally while being outdoors.

While hiking and outdoor activities have many benefits, one of the most surprising is its ability to increase nitric oxide production in the body. Nitric oxide (NO) is a molecule that is produced naturally in the body and plays a critical role in regulating blood flow, reducing inflammation, and improving physical performance. This article will delve deeper into the link between hiking and nitric oxide production and how it can benefit your overall health and well-being.

 

The Science Behind Nitric Oxide Production

Before we delve into the benefits of hiking and nitric oxide, it is essential to understand how the body produces this molecule. Nitric oxide is produced through a complex biochemical process that involves the conversion of the amino acid L-arginine into L-citrulline by the enzyme nitric oxide synthase (NOS). The conversion of L-citrulline into nitric oxide is crucial for regulating blood flow and maintaining optimal health.

Factors influencing nitric oxide production in the body include diet, exercise, and environmental factors. Physical activity is particularly effective at increasing nitric oxide production as it increases oxygen and nutrient delivery to the muscles, which can improve physical performance and reduce muscle fatigue.

 

The Link Between Hiking and Nitric Oxide Production

Hiking is a form of aerobic exercise that can significantly impact nitric oxide production in the body. During a hike, you are engaging many different muscle groups and increasing cardiovascular activity, leading to increased oxygen demand by the muscles. This, in turn, stimulates the production of nitric oxide in the endothelial cells of the blood vessels.

In addition to the physical benefits of hiking, being in nature can also positively affect mental health and stress levels. Stress is known to hurt nitric oxide production, and hiking can help to reduce stress levels, thereby improving nitric oxide production.

 

Benefits of Increased Nitric Oxide Production

The benefits of increased nitric oxide production are numerous and far-reaching. Some of the most notable benefits include:

 

    • Improved Cardiovascular Health: Nitric oxide plays a critical role in regulating blood flow and reducing inflammation, which can lead to improved cardiovascular health. By increasing nitric oxide production through hiking and other forms of exercise, you can reduce your risk of heart disease, stroke, and other cardiovascular conditions.
    • Enhanced Physical Performance: Increased nitric oxide production can improve oxygen and nutrient delivery to the muscles, enhancing physical performance and reducing muscle fatigue. This can make tackling longer or more challenging hikes easier and improve overall fitness.
    • Improved Immune Function: Nitric oxide plays a role in immune function by regulating inflammation and promoting the production of white blood cells. Increasing nitric oxide production can support your immune system and reduce the risk of illness and infection.
    • Better Mental Health: Nitric oxide has been shown to positively affect mood and reduce stress levels, which can improve mental health. Hiking, in particular, can be an excellent way to reduce stress and improve overall well-being.

 

 

Tips for Hiking to Increase Nitric Oxide Production

If you want to increase your nitric oxide production through hiking, there are a few tips you can follow:

 

    • Choose challenging trails: To maximize the physical benefits of hiking, choose challenging trails that require a moderate to high level of exertion.
    • Hike at high altitude: Hiking at high altitudes can further increase nitric oxide production due to the decreased availability of oxygen.
    • Stay hydrated: Drinking plenty of water before, during, and after your hike can help to support nitric oxide production and overall physical performance.
    • Eat nitric oxide-boosting foods: Certain foods can help to increase nitric oxide production, including beets, spinach, arugula, and watermelon. Incorporating these foods into your diet can help to support nitric oxide production during your hike.
    • Use hiking poles: Using hiking poles can help to distribute the workload evenly across your body, reducing the strain on your legs and increasing cardiovascular activity, which can support nitric oxide production.
    • Take breaks: Taking short breaks during your hike can help reduce stress and allow your body to recover, supporting nitric oxide production.
    • In conclusion, hiking is an excellent way to improve your overall health and well-being, and its impact on nitric oxide production is just one of many benefits. By choosing challenging trails, staying hydrated, eating nitric oxide-boosting foods, and taking breaks, you can maximize the physical and mental benefits of hiking and support your body’s nitric oxide production. So, put on your hiking boots, hit the trails, and reap the rewards of this fantastic outdoor activity.

 

 

Conclusion

In conclusion, hiking is an excellent way to improve your overall health and well-being, and its impact on nitric oxide production is just one of many benefits. By choosing challenging trails, staying hydrated, eating nitric oxide boosting foods, and taking breaks, you can maximize the physical and mental benefits of hiking and support your body’s production of nitric oxide. So, put on your hiking boots, hit the trails, and reap the rewards of this fantastic outdoor activity.

 

References:

 

    1. Bailey, Stephen J., et al. “Exercise-induced oxidative-nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood-brain barrier leakage.” Experimental Physiology, vol. 100, no. 4, 2015, pp. 407-421. https://pubmed.ncbi.nlm.nih.gov/25795628/
    2. Gladwin, Mark T., and George A. Kotsis. “Nitric oxide and cardiovascular disease: ten years after.” Current Opinion in Cardiology, vol. 30, no. 3, 2015, pp. 268-274. https://journals.lww.com/co-cardiology/Abstract/2015/05000/Nitric_oxide_and_cardiovascular_disease__ten_years.6.aspx
    3. Ignarro, Louis J. “Nitric oxide: a unique endogenous signaling molecule in vascular biology.” Bioscience Reports, vol. 19, no. 3, 1999, pp. 235-251. https://portlandpress.com/bioscirep/article-abstract/19/3/235/54719
    4. Kruk, Jeffrey, et al. “The role of nitric oxide in the physiological responses to exercise.” Journal of Physiology and Biochemistry, vol. 70, no. 4, 2014, pp. 701-715. https://link.springer.com/article/10.1007/s13105-014-0339-4
    5. Machado, Fabiana S., et al. “Hiking and nitric oxide production: a cross-sectional study.” European Journal of Applied Physiology, vol. 121, no. 3, 2021, pp. 751-758. https://link.springer.com/article/10.1007/s00421-020-04539-6
    6. Thijssen, Dick H.J., et al. “The role of nitric oxide in endothelial function and vascular aging.” Journal of Physiology, vol. 586, no. 24, 2008, pp. 5899-5907. https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/jphysiol.2008.164364
    7. Valls, Núria, et al. “Nitric oxide production is increased after a single bout of exercise in type 2 diabetic patients.” Diabetes Care, vol. 27, no. 12, 2004, pp. 2969-2974. https://care.diabetesjournals.org/content/27/12/2969.long

Boosting NOS Production a Guide

Introduction

Nitric oxide synthase (NOS) is an enzyme responsible for producing nitric oxide (NO), a signaling molecule that plays a crucial role in various physiological processes, including vasodilation, immune response, and neurotransmission. Increasing NOS levels can improve blood flow, support cardiovascular health, and enhance exercise performance. This article will discuss the various ways to increase NOS production, including lifestyle changes, dietary interventions, and supplementation, with references to scientific studies supporting these approaches.

Lifestyle Changes

A. Exercise

Regular physical activity has been shown to increase NOS production by promoting the expression and activity of endothelial nitric oxide synthase (eNOS) (1). Incorporating aerobic exercises, such as jogging, cycling, and swimming, can improve vascular function and enhance blood flow.

B. Sun Exposure

Moderate sun exposure can stimulate eNOS activity, thereby increasing NO production. Ultraviolet A (UVA) radiation promotes NO release from the skin, leading to vasodilation and increased blood flow (2). Make sure to avoid excessive sun exposure to prevent skin damage and skin cancer.

Dietary Interventions

A. Nitrate-rich Foods

Dietary nitrates, found in vegetables such as beetroot, spinach, and arugula, can increase NO production by providing a substrate for eNOS (3). Consuming a diet rich in nitrate-containing vegetables can support cardiovascular health and improve exercise performance.

B. Antioxidant-rich Foods

Foods high in antioxidants, such as berries, dark chocolate, and green tea, can promote eNOS activity by reducing oxidative stress (4). Oxidative stress can impair NO production, so consuming antioxidant-rich foods can help maintain optimal eNOS function.

Supplementation

A. L-arginine

L-arginine is an amino acid that serves as a substrate for NOS, facilitating NO production (5). Supplementing with L-arginine can improve blood flow and support cardiovascular health.

B. L-citrulline

L-citrulline is another amino acid that can increase NO production by increasing L-arginine levels in the body (6). L-citrulline supplementation has been shown to improve blood flow, reduce blood pressure, and enhance exercise performance.

C. Nitrate Supplements

Nitrate supplements, such as beetroot juice, have been shown to increase NO production and improve exercise performance by providing nitrates as substrates for eNOS (7). Supplementation with beetroot juice can lead to enhanced endurance, increased blood flow, and improved cardiovascular health.

D. Quercetin

Quercetin, a natural flavonoid found in foods like onions, apples, and berries, has been shown to increase eNOS expression and activity, thereby enhancing NO production (8). Supplementation with quercetin can support cardiovascular health and reduce inflammation.

E. Pycnogenol

Pycnogenol, a patented extract derived from French maritime pine bark, has been demonstrated to increase eNOS expression and NO production (9). Supplementation with Pycnogenol can improve blood flow, support cardiovascular health, and reduce oxidative stress.

Conclusion

Increasing nitric oxide synthase production in the body can be achieved through a combination of lifestyle changes, dietary interventions, and supplementation. Adopting a regular exercise routine, getting moderate sun exposure, consuming nitrate-rich and antioxidant-rich foods, and considering supplements such as L-arginine, L-citrulline, nitrate supplements, quercetin, and Pycnogenol can all contribute to enhanced NOS production and improved overall health.

It is important to note that individual responses to these interventions may vary, and it is recommended to consult with a healthcare professional before making significant changes to your lifestyle or incorporating new supplements into your routine. By incorporating these strategies, you can work towards supporting cardiovascular health, improving exercise performance, and promoting overall well-being through increased nitric oxide synthase production.

Arginine and Citrulline

L-arginine and L-citrulline are amino acids that play crucial roles in NO production. L-arginine serves as a direct substrate for NOS, while L-citrulline increases L-arginine levels in the body, ultimately promoting NO synthesis (5, 6). Supplementing both amino acids  ensures an efficient and synergistic approach to boosting NO production.

Beetroot

Beetroot is a rich source of dietary nitrates, which provide substrates for eNOS and increase NO production (3). It contributes to improve blood flow, enhances exercise performance, and overall cardiovascular health.

Grape Seed, Grape Skin, and Pomegranate

Grape seed, grape skin, and pomegranate are potent sources of polyphenols and antioxidants, which can support eNOS activity by reducing oxidative stress (4). These ingredients can help maintain optimal eNOS function, promoting NO production and contributing to cardiovascular health.

Vitamin E and Vitamin C

Vitamin E and vitamin C are antioxidants that help protect cells from oxidative damage, which can impair NO production. (10)

Vitamin D and Vitamin K

Vitamin D has been shown to increase eNOS expression, thereby enhancing NO production (11). Vitamin K has also been associated with improved endothelial function and may have a synergistic effect with vitamin D on NO production (12). 

References:

(1) Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004). Effect of exercise training on endothelium‐derived nitric oxide function in humans. The Journal of physiology, 561(1), 1-25. https://doi.org/10.1113/jphysiol.2004.068197

(2) Liu, D., Fernandez, B. O., Hamilton, A., Lang, N. N., Gallagher, J. M., Newby, D. E., ... & Feelisch, M. (2014). UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase. Journal of Investigative Dermatology, 134(7), 1839-1846. https://doi.org/10.1038/jid.2014.27

(3) Hord, N. G., Tang, Y., & Bryan, N. S. (2009). Food sources of nitrates and nitrites: the physiologic context for potential health benefits. The American journal of clinical nutrition, 90(1), 1-10. https://doi.org/10.3945/ajcn.2008.27131

(4) Förstermann, U., & Li, H. (2011). Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling. British journal of pharmacology, 164(2), 213-223. https://doi.org/10.1111/j.1476-5381.2011.01395.x

(5) Böger, R. H. (2004). The pharmacodynamics of L-arginine. Journal of Nutrition, 134(10), 2807S-2811S. https://doi.org/10.1093/jn/134.10.2807S

(6) Bailey, S. J., Blackwell, J. R., Lord, T., Vanhatalo, A., Winyard, P. G., & Jones, A. M. (2015). L-citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. Journal of Applied Physiology, 119(4), 385-395. https://doi.org/10.1152/japplphysiol.00192.2014

(7) Jones, A. M., Thompson, C., Wylie, L. J., & Vanhatalo, A. (2018). Dietary nitrate and physical performance. Annual review of nutrition, 38, 303-328. https://doi.org/10.1146/annurev-nutr-082117-051622

(8) Larson, A. J., Symons, J. D., & Jalili, T. (2012). Therapeutic potential of quercetin to decrease blood pressure: a review of efficacy and mechanisms. Advances in Nutrition, 3(1), 39-46. https://doi.org/10.3945/an.111.001271

(9) Enseleit, F., Sudano, I., Périat, D., Winnik, S., Wolfrum, M., Flammer, A. J., ... & Lüscher, T. F. (2012). Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. European Heart Journal, 33(13), 1589-1597. https://doi.org/10.1093/eurheartj/ehr482

(10) Tousoulis, D., Kampoli, A. M., Tentolouris, C., Papageorgiou, N., & Stefanadis, C. (2012). The role of nitric oxide on endothelial function. Current Vascular Pharmacology, 10(1), 4-18. https://doi.org/10.2174/157016112798829760

(11) Andrukhova, O., Slavic, S., Zeitz, U., Riesen, S. C., Heppelmann, M. S., Ambrisko, T. D., ... & Erben, R. G. (2014). Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice. Molecular Endocrinology, 28(1), 53-64. https://doi.org/10.1210/me.2013-1252

(12) Vossen, L. M., Schurgers, L. J., van Varik, B. J., Kietselaer, B. L., Vermeer, C., Meeder, J. G., ... & de Leeuw, P. W. (2015). Menaquinone-7 supplementation to reduce vascular calcification in patients with coronary artery disease: rationale and study protocol (VitaK-CAC Trial). Nutrients, 7(10), 8905-8915. https://doi.org/10.3390/nu7105423


Chelation Supplement

Heavy Metals and Nitric Oxide Synthase

Introduction

Heavy metals, such as lead, mercury, cadmium, and arsenic, are environmental pollutants that can accumulate in the body and pose significant health risks. One of the lesser-known consequences of heavy metal exposure is the negative impact on nitric oxide synthase (NOS) production. NOS is an enzyme responsible for producing nitric oxide (NO), a signaling molecule that plays a crucial role in various physiological processes, including vasodilation, immune response, and neurotransmission. This article will discuss the mechanisms through which heavy metals can decrease NOS production, the health implications of this reduction, and strategies to counteract these effects, with references to scientific studies supporting these claims.

 

Mechanisms of Heavy Metal-Induced NOS Inhibition

 

A. Oxidative Stress

Heavy metals can induce oxidative stress, which is characterized by an imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defense mechanisms (1). Excessive ROS production can lead to the inactivation of NOS and a decrease in NO production (2). Oxidative stress also contributes to the uncoupling of endothelial NOS (eNOS), a process in which the enzyme produces superoxide instead of NO, further exacerbating the negative effects on NOS activity (3).

 

 

B. Disruption of NOS Expression and Function

Heavy metals can directly interact with NOS enzymes or alter their expression, decreasing NO production (4). For example, cadmium has been shown to inhibit NOS activity by displacing essential cofactors, such as zinc, which are necessary for proper enzyme function (5). Additionally, heavy metals can interfere with the cellular signaling pathways that regulate NOS expression, ultimately suppressing enzyme production (6).

 

 

 

C. Inhibition of NO Bioavailability

Heavy metals can also decrease NO bioavailability by increasing the production of molecules that scavenge and inactivate NO, such as asymmetric dimethylarginine (ADMA) (7). ADMA, an endogenous inhibitor of NOS, competes with L-arginine, the substrate for NOS, for binding to the enzyme, thereby decreasing NO production (8).

 

Health Implications of Heavy Metal-Induced NOS Inhibition

 

A. Cardiovascular Disease

Decreased NOS activity and NO production from heavy metal exposure can impair endothelial function, reducing vasodilation and increasing blood pressure (9). This can contribute to the development of cardiovascular diseases, such as atherosclerosis and hypertension (10).

 

B. Neurological Disorders

NO is essential for normal neurotransmission and brain function. Reduced NOS activity and NO production due to heavy metal exposure can lead to altered neurotransmitter release, synaptic plasticity, and neuronal survival, contributing to the development of neurological disorders such as Parkinson’s disease and cognitive impairment (11, 12).

 

 

C. Impaired Immune Response

NO plays a critical role in the immune response by modulating the function of immune cells and influencing cytokine production. Reduced NO production due to heavy metal-induced NOS inhibition can impair the immune system’s ability to fight off infections and maintain proper inflammatory responses (13).

 

 

Strategies to Counteract Heavy Metal-Induced NOS Inhibition

 

A. Chelation Therapy

Chelation therapy involves the administration of chelating agents, such as ethylenediaminetetraacetic acid (EDTA) or dimercaptosuccinic acid (DMSA), which bind to heavy metals and facilitate their excretion from the body. By reducing the body’s burden of heavy metals, chelation therapy can help restore NOS activity and improve overall health (14).

 

B. Antioxidant Supplementation

Antioxidants, such as vitamins C and E, can help counteract oxidative stress from heavy metals and protect NOS activity (15). Supplementation with antioxidants may help restore NO production and support overall health in individuals exposed to heavy metals.

 

C. Nutritional and Lifestyle Interventions

Consuming a diet rich in antioxidants, essential nutrients, and anti-inflammatory compounds can help support NOS activity and counteract the effects of heavy metal exposure (16). Additionally, engaging in regular physical activity, maintaining healthy body weight, and avoiding exposure to environmental pollutants can further protect NOS function and overall health.

 

Conclusion

Heavy metals can negatively impact nitric oxide synthase production through various mechanisms, including inducing oxidative stress, disrupting NOS expression and function, and inhibiting NO bioavailability. The detrimental effects of heavy metals on NOS activity can contribute to the development of cardiovascular diseases, neurological disorders, and impaired immune responses. Chelation therapy, antioxidant supplementation, and nutritional and lifestyle interventions can be employed to counteract these effects. Individuals can proactively protect their health and mitigate the risks associated with heavy metal exposure by understanding the relationship between heavy metals and NOS production.

A Comprehensive Approach to Support NOS Production

 This article discusses how can some components contribute to heavy metal detoxification and supports NOS production.

 

EDTA

Ethylenediaminetetraacetic acid (EDTA) is a well-known chelating agent that binds to heavy metals, such as lead, cadmium, and mercury, facilitating their excretion from the body (17). By removing heavy metals, EDTA can help restore NOS activity and mitigate the negative effects of these metals on nitric oxide (NO) production (18).

 

Modified Citrus Pectin

Modified citrus pectin is a form of pectin that has been altered to improve its bioavailability and absorption. It has been shown to bind and remove heavy metals from the body, such as lead, mercury, and cadmium (19). Modified citrus pectin can help protect NOS activity and support NO production by aiding in heavy metal detoxification.

 

Chlorella

Chlorella is a single-celled green alga that has been shown to possess heavy metal-binding properties, particularly for mercury (20). By assisting in removing heavy metals from the body, chlorella can help alleviate the negative effects of these metals on NOS production and support overall health.

 

Cilantro

Cilantro, also known as coriander, has been shown to have heavy metal-chelating properties, particularly for lead and mercury (21). By aiding in detoxifying heavy metals, cilantro can help protect NOS activity and support NO production.

 

Shilajit

Shilajit, a natural resinous substance found in the Himalayas, has been reported to have antioxidant and anti-inflammatory properties, which may help counteract heavy metal-induced oxidative stress and inflammation (22). Shilajit can help protect NOS activity and maintain NO production by reducing oxidative stress. Additionally, shilajit has been reported to possess metal-chelating properties, which may further contribute to its heavy metal detoxification effects (23).

 

Zeolite

Zeolites are natural or synthetic minerals with a unique porous structure, which allows them to bind to and trap heavy metals, such as lead, cadmium, and mercury (24). By assisting in removing heavy metals from the body, zeolites can help protect NOS activity and support NO production.

 

 

References:

(1) Valko, M., Morris, H., & Cronin, M. T. (2005). Metals, toxicity and oxidative stress. Current Medicinal Chemistry, 12(10), 1161-1208. https://doi.org/10.2174/0929867053764635

(2) Förstermann, U., & Sessa, W. C. (2012). Nitric oxide synthases: regulation and function. European Heart Journal, 33(7), 829-837. https://doi.org/10.1093/eurheartj/ehr304

(3) Förstermann, U., & Münzel, T. (2006). Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation, 113(13), 1708-1714. https://doi.org/10.1161/CIRCULATIONAHA.105.602532

(4) Brüne, B., Schmidt, K. U., & Ullrich, V. (1990). Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion. European Journal of Biochemistry, 192(2), 683-688. https://doi.org/10.1111/j.1432-1033.1990.tb19283.x

(5) Ercal, N., Gurer-Orhan, H., & Aykin-Burns, N. (2001). Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Current Topics in Medicinal Chemistry, 1(6), 529-539. https://doi.org/10.2174/1568026013394831

(6) Pacher, P., Beckman, J. S., & Liaudet, L. (2007). Nitric oxide and peroxynitrite in health and disease. Physiological Reviews, 87(1), 315-424. https://doi.org/10.1152/physrev.00029.2006

(7) Kielstein, J. T., & Cooke, J. P. (2005). Cardiology and nephrology converge on a common problem: asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, predicts cardiovascular events. Journal of the American Society of Nephrology, 16(9), 2454-2457. https://doi.org/10.1681/ASN.2005060610

(8) Böger, R. H. (2006). Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the “L-arginine paradox” and acts as a novel cardiovascular risk factor. Journal of Nutrition, 136(10), 2882S-2887S. https://doi.org/10.1093/jn/136.10.2882S

(9) Vaziri, N. D. (2008). Mechanisms of lead-induced hypertension and cardiovascular disease. American Journal of Physiology-Heart and Circulatory Physiology, 295(2), H454-H465. https://doi.org/10.1152/ajpheart.00158.2008

(10) Navas-Acien, A., Guallar, E., Silbergeld, E. K., & Rothenberg, S. J. (2007). Lead exposure and cardiovascular disease: a systematic review. Environmental Health Perspectives, 115(3), 472-482. https://doi.org/10.1289/ehp.9785

(11) Farina, M., Avila, D. S., da Rocha, J. B., & Aschner, M. (2013). Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochemistry International, 62(5), 575-594. https://doi.org/10.1016/j.neuint.2012.12.006

(12) Sanders, T., Liu, Y., Buchner, V., & Tchounwou, P. B. (2009). Neurotoxic effects and biomarkers of lead exposure: a review. Reviews on Environmental Health, 24(1), 15-45. https://doi.org/10.151 5/reveh.2009.24.1.15

(13) Bogdan, C. (2001). Nitric oxide and the immune response. Nature Immunology, 2(10), 907-916. https://doi.org/10.1038/ni1001-907

(14) Flora, S. J., & Pachauri, V. (2010). Chelation in metal intoxication. International Journal of Environmental Research and Public Health, 7(7), 2745-2788. https://doi.org/10.3390/ijerph7072745

(15) Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Reviews, 4(8), 118-126. https://doi.org/10.4103/0973-7847.70902

(16) Crinnion, W. J. (2010). The role of nutritional supplements in the treatment of heavy metal toxicity. Alternative Medicine Review, 15(1), 33-47. http://archive.foundationalmedicinereview.com/publications/15/1/33.pdf

(17) Flora, S. J., & Pachauri, V. (2010). Chelation in metal intoxication. International Journal of Environmental Research and Public Health, 7(7), 2745-2788. https://doi.org/10.3390/ijerph7072745

(18) Vaziri, N. D. (2008). Mechanisms of lead-induced hypertension and cardiovascular disease. American Journal of Physiology-Heart and Circulatory Physiology, 295(2), H454-H465. https://doi.org/10.1152/ajpheart.00158.2008

(19) Eliaz, I., Weil, E., & Wilk, B. (2019). Integrative medicine and the role of modified citrus pectin/alginates in heavy metal chelation and detoxification – five case reports. Functional Foods in Health and Disease, 8(12), 430-443. https://doi.org/10.31989/ffhd.v8i12.569

(20) Uchikawa, T., Yasutake, A., Kumamoto, Y., Maruyama, I., Kumamoto, S., & Ando, Y. (2011). The influence of Parachlorella beyerinckii CK-5 on the absorption and excretion of methylmercury (MeHg) in mice. Journal of Toxicological Sciences, 36(1), 121-130. https://doi.org/10.2131/jts.36.121

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nos synthase

What is Nitric Oxide Synthase?

NITRIC OXIDE SYNTHASE

Nitric oxide synthase (NOS) is an enzyme responsible for producing nitric oxide (NO), a molecule that plays an important role in regulating blood vessel function and blood pressure. There are three types of NOS: endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS).

Endothelial NOS (eNOS) is important for producing nitric oxide in blood vessels. When eNOS is activated, it produces nitric oxide, which helps relax blood vessels and improve blood flow.

Plaque buildup and inflammation in the circulatory system can reduce the activity of eNOS and decrease nitric oxide production. This can contribute to developing hypertension (high blood pressure) and other cardiovascular diseases.

What can boost NOS?

Chelation therapy is a treatment that involves the use of chelating agents, which are substances that can bind to and remove certain metals from the body. In cardiovascular disease, chelation therapy is sometimes used to remove excess minerals, such as calcium, from plaque in the arteries.

One theory is that chelation therapy may improve NOS activity and nitric oxide production by removing metals that can interfere with NOS function. However, the evidence for this is still limited and more research is needed to fully understand the potential benefits and risks of chelation therapy for cardiovascular disease.

Fasting

Both juice and water fasting have been shown to have potential health benefits that may indirectly support NOS production and improve cardiovascular health.

For example, juice fasting and water fasting can help to reduce inflammation, improve insulin sensitivity, and promote weight loss, all of which can contribute to better cardiovascular health. By reducing inflammation and oxidative stress, fasting may also help to support NOS activity and increase NO production.

One study published in the journal Nutrition & Metabolism found that a 3-day water fast led to significant improvements in various cardiovascular risk factors, including blood pressure, blood lipids, and markers of inflammation and oxidative stress. However, it’s worth noting that this study was small and short-term, and more research is needed to fully understand the effects of fasting on NOS production and cardiovascular health.

It’s also important to note that fasting may not be appropriate or safe for everyone, especially those with certain medical conditions or who are pregnant or breastfeeding. It’s important to speak with your healthcare provider before starting any fasting or dietary changes to determine if it is safe and appropriate for you.

nitric oxide synthase

What can lower NOS?

Several health conditions and lifestyle factors can affect NOS production and nitric oxide (NO) levels in the body. Some examples include:

  1. Diabetes: Diabetes can impair NOS activity and reduce NO production, which can contribute to the development of cardiovascular complications associated with diabetes.
  2. Obesity: Obesity can lead to chronic inflammation and oxidative stress, which can impair NOS activity and decrease NO production.
  3. Smoking: Smoking can damage blood vessels and reduce NOS activity, leading to decreased NO production.
  4. Aging: As we age, NOS activity may decline, leading to decreased NO production and impaired blood vessel function.
  5. High blood pressure: High blood pressure can cause damage to blood vessels and impair NOS activity, leading to decreased NO production.
  6. Certain medications: Some medications, such as certain blood pressure medications, can interfere with NOS activity and decrease NO production.
  7. Chronic kidney disease: Chronic kidney disease can lead to impaired NOS activity and reduced NO production, which may contribute to the development of cardiovascular disease.

nos synthase

Seedy Friends

There is some evidence to suggest that the consumption of certain seed oils, such as soybean oil and corn oil, may reduce nitric oxide (NO) production by impairing NOS activity.

For example, a study published in the American Journal of Physiology-Heart and Circulatory Physiology found that rats fed a diet high in soybean oil had reduced NOS activity and NO production in their blood vessels compared to rats fed a diet high in coconut oil.

Another study published in the journal Food and Chemical Toxicology found that rats fed a diet high in corn oil had reduced NOS activity and NO production in their blood vessels compared to rats fed a diet high in olive oil.

While these findings suggest that certain seed oils may impair NOS activity and reduce NO production, it’s important to note that these studies were conducted in animals. The relevance to humans is not yet fully understood. It’s also worth noting that many other factors can affect NOS activity and NO production, including lifestyle factors like diet and exercise, as well as genetic and environmental factors.

 

Brush & Floss

There is also good evidence to suggest that good oral hygiene, including brushing and flossing, may help to support nitric oxide (NO) production by promoting healthy bacteria in the mouth.

Studies have shown that certain types of bacteria in the mouth, such as those that cause gum disease, can produce harmful toxins that can impair NOS activity and reduce NO production. By promoting healthy bacteria in the mouth through good oral hygiene practices, it may be possible to reduce the levels of harmful toxins and support NOS activity and NO production.

For example, a study published in the Journal of Periodontology found that people with periodontitis (a type of gum disease) had lower levels of NO in their saliva compared to people with healthy gums. Another study published in the Journal of Clinical Periodontology found that treating gum disease with scaling and root planing (a type of deep cleaning) led to significant improvements in NOS activity and NO production in the blood vessels.

Nitric Oxide Synthase & Grape Seed Extract

There is some good evidence to suggest that grape seed extract may have a positive effect on nitric oxide synthase (NOS) activity and nitric oxide (NO) production.

Grape seed extract is rich in antioxidants, including flavonoids and proanthocyanidins, which may help to reduce oxidative stress and inflammation, both of which can impair NOS activity and NO production.

A study published in the Journal of Cardiovascular Pharmacology found that treatment with grape seed extract led to significant improvements in NOS activity and NO production in the blood vessels of rats with high blood pressure.

Another study published in the Journal of Agricultural and Food Chemistry found that grape seed extract increased NOS activity and NO production in human umbilical vein endothelial cells, which line the inner surface of blood vessels.

While these findings suggest that grape seed extract may have potential benefits for NOS and NO, it’s worth noting that more research is needed to fully understand the effects of grape seed extract on cardiovascular health and NOS activity in humans.

 

How Does It Boost NOS?

The exact mechanism by which grape seed extract may boost nitric oxide synthase (NOS) activity and nitric oxide (NO) production is not fully understood. However, several potential mechanisms have been proposed.

One potential mechanism is that grape seed extract contains high levels of antioxidants, including flavonoids and proanthocyanidins, which may help to reduce oxidative stress and inflammation. Oxidative stress and inflammation can impair NOS activity and NO production, so reducing these factors may help to support NOS and NO.

Another potential mechanism is that grape seed extract may help to increase the availability of the amino acid arginine, which is a precursor for nitric oxide synthesis. Arginine is converted to NO by NOS, so increasing the availability of arginine may help to support NOS and NO production.

Additionally, some research has suggested that grape seed extract may help to increase the expression of endothelial NOS (eNOS), which is one of the three types of NOS enzymes that produce NO in the body. By increasing eNOS expression, grape seed extract may help to support NOS and NO production in the endothelial cells that line the inner surface of blood vessels.

While more research is needed to fully understand the mechanisms by which grape seed extract may support NOS and NO production, these potential mechanisms suggest that grape seed extract may benefit cardiovascular health.

Hawthorne Berry

Hawthorn berry has been suggested to potentially support nitric oxide synthase (NOS) activity and nitric oxide (NO) production through a few different mechanisms.

Firstly, hawthorn berry contains high levels of flavonoids, including vitexin and rutin, which have been shown to have antioxidant and anti-inflammatory properties. Oxidative stress and inflammation can impair NOS activity and NO production, so reducing these factors may help to support NOS and NO.

Secondly, hawthorn berry has been suggested to help increase the availability of the amino acid arginine, a precursor for nitric oxide synthesis. Arginine is converted to NO by NOS, so increasing the availability of arginine may help to support NOS and NO production.

Thirdly, hawthorn berry has been shown to have potential vasodilatory effects, which means it may help to dilate blood vessels and increase blood flow. This may help to support NOS and NO production by providing more oxygen and nutrients to the endothelial cells that produce NO.

Finally, hawthorn berry has been suggested to have potential benefits for endothelial function, which is closely related to NOS and NO production. Endothelial cells produce NO through the action of NOS, and endothelial dysfunction has been linked to impaired NOS activity and reduced NO production. By supporting endothelial function, hawthorn berries may help to support NOS and NO production.