In our increasingly polluted environment, it’s essential to explore innovative strategies to maintain our bodies in a state free from damaging toxins and impurities. Global pollution and ecological challenges have led to a surge of interest in oral chelation supplements. Particularly popular are those targeting heavy metal detoxification. Contaminated food, beverages, manufacturing processes, and pesticides can all contribute to an unwanted toxic burden.

It is essential to understand the methods for removing toxins from our bodies and the potential damage they can cause.

Prominent in the field of Chelation is Chelanox by Bionox®. Chelanox is a potent blend of botanicals engineered to counter the harmful impacts of heavy metals in our systems. We’ve meticulously researched each ingredient to curate the most effective formulation. Our goal today is to enlighten you about the intricacies of Chelation and the rationale behind our ingredient selection.


Exploring Oral Chelation

Oral chelation represents a health or dietary intervention that leverages certain compounds to purge the body of detrimental toxins, mainly heavy metals.

Known as chelating agents, these elements bind with the toxins and heavy metals inside the body. This helps the body detox by creating a stable chelate compound. The body then safely removes this compound through urine or feces. Initially used to fight against heavy metal toxicity, the application of this therapy has expanded over time.

The introduction of products like Chelanox has expanded its scope to encompass preventative health and overall wellness.

Oral chelation could play a pivotal role in protecting and elevating your health:

  1. Diminishing Toxic Burden – The main advantage of oral chelation is the diminution of toxic burden, primarily heavy metals like arsenic, lead, and mercury.
  2. Maintaining Heart Health – Research indicates that chelation therapy could decrease the accumulation of specific types of plaque in arteries, thereby facilitating optimal cardiovascular well being.
  3. Preserving Kidney Health: By alleviating the load of toxins and heavy metals, oral chelation products could help maintain the health of your kidneys.
  4. Preserving Neurological Function – Chelation therapy could help maintain neurological function by expelling heavy metals from your body.
  5. Immune System – Chelation therapy can boost immune system health and general vitality by lessening the total toxic load on the body.
  6. Boosting Vitality Levels – Chelation supplement users often report a surge in vitality levels. This is likely due to reduced systemic stress caused by toxins and heavy metals. Increased vitality leads to an overall better feeling and increased activity, which is always beneficial!
  7. Gut Health – Chelation therapy could bolster gut health by expelling toxins from the body.
  8. Enhancing Skin Health – Chelation therapy might boost skin health by facilitating the expulsion of toxins, leading to a cleaner, more glowing complexion.
  9. Maximizing Nutrient Uptake – Reduced toxic interference may allow the body to absorb and utilize essential nutrients from your diet more effectively.
  10. Maintaining Liver Health – The liver plays a key role in detoxification within the body. Chelation could foster healthier liver function by assisting the body in toxin removal.

oral chelation supplements

Reducing toxic load

Let’s examine the key ingredients in our Chelanox product to understand their functions:

  1. EDTA Calcium Disodium.  A study in the Journal of Advancement in Medicine found that oral intake of EDTA can be beneficial for reducing lead toxicity.1
  2. Chlorella Algae.  A recent study published in Nutrition Research and Practice concluded that chlorella could decrease the amount of dioxin in breast milk and in the body generally. 2
  3. Modified Citrus Pectin. MCP is a type of pectin that has been altered to be more easily absorbed by the digestive tract. A study in Phytotherapy Research indicated that MCP can help reduce lead levels in the body. 3
  4. Cilantro Leaf Extract. A study that was published in the Journal of Traditional Chinese Medicine suggests that cilantro can expedite the body’s excretion of lead and mercury. 4
  5. Shilajit. Shilajit is rich in fulvic and humic acids, which may possess chelating properties, according to a study in the Journal of Ethnopharmacology. 5
  6. Zeolite. Zeolites are volcanic minerals that can act like magnets for toxins. Research has shown that zeolite clinoptilolite can trap and remove harmful toxins, including heavy metals, from the body. 6
  7. N-Acetyl Cysteine. Is known to enhance the production of glutathione. 7
  8. Alpha Lipoic Acid. ALA is a potent antioxidant that can bind with toxic free radicals and help remove them from the body. A study in Free Radical Biology & Medicine found that ALA can help the body detoxify from heavy metals. 8
  9. Uva Ursi Leaf and Milk Thistle Seed . These ingredients, traditionally used in herbal medicine, are included for their diuretic and liver-supporting properties, respectively, thus aiding in the detoxification process. 910

How does oral chelation enhance heart health?

Chelation therapy has been studied for its potential benefits in treating cardiovascular disease, mainly by addressing atherosclerosis. Atherosclerosis is a condition characterized by the buildup of plaques in the arteries.

These plaques, primarily comprised of cholesterol, fat, and calcium, can restrict blood flow and potentially lead to severe cardiovascular events like heart attack or stroke.

While the mechanism isn’t entirely understood, some theories suggest that the calcium-disodium form of EDTA could bind with the calcium in these plaques, thus helping to reduce their size and improve blood flow. For this reason, we use this form of EDTA in Chelanox.

Trial to Assess Chelation Therapy

One of the most significant studies in this area is the Trial to Assess Chelation Therapy (TACT). This doubleblind, placebo controlled study, sponsored by the National Institutes of Health, was designed to determine the safety and effectiveness of EDTA chelation therapy in individuals with coronary artery disease.

The results, published in the Journal of the American Medical Association (JAMA) 11, showed that a course of 40 infusions of a high-dose multivitamin and disodium EDTA chelation solution modestly reduced the risk of adverse cardiovascular outcomes, including recurrent heart attacks, stroke, and death, among study participants who had previously suffered a heart attack.

Additionally, a follow-up study, TACT2 12, is currently underway to further explore the potential benefits of EDTA chelation therapy for post-heart attack patients with diabetes, as this subgroup seemed to benefit the most in the initial TACT study.

Intravenous EDTA

It’s important to note that oral chelation may not offer the same level of cardiovascular benefits as intravenous EDTA. This is because of the lower absorption rate of oral EDTA. At Bionox, we use acid resistant capsules in our chelation product to ensure better absorption of EDTA calcium. This occurs because the capsules allow it to bypass the stomach and enter the intestines for greater potential uptake. You should not use EDTA in capsule form unless it is in acid resistant capsules. Only EDTA Calcium Disodium should be used for maximum effect and safety.

Binding of Chelating Agents to Toxins

When we say chelating agents bind to toxins, we refer to a chemical process where the chelating agent forms a complex with the toxin. Chelating agents have multiple binding sites. These sites allow them to form stable complexes with metal ions. In other words, they connect with and bind to them. This ability to bind is based on the atomic structure of the chelating agent and the toxin.

Take, for example, EDTA Calcium, one of our formula’s main ingredients and a chelating agent. EDTA has a negative charge, while heavy metals like lead and mercury have a positive charge. Due to this opposite charge, the EDTA can bind to the heavy metal to form a neutral compound. This process is akin to a lock and key, where the chelating agent (the lock) fits perfectly with the metal ion (the key).

Where Do the Toxins Go?

Once the chelating agent binds to the toxin, forming a stable complex, this compound becomes water soluble and can be safely removed from the body. This process mainly occurs through renal excretion, meaning the complex is expelled in urine. Some chelating agents can also promote toxin removal through the feces.

There are several tests available to measure your body’s toxic load and determine if chelation therapy is effective:

1. **Heavy Metal Testing** This involves looking at blood, urine, or hair samples. A baseline measurement of heavy metal levels is established before starting chelation therapy. Subsequent tests are conducted to monitor any decreases in metal levels during or after the therapy.

2. **Chelation Challenge Test** This test involves taking a chelating agent and collecting 24-hour urine samples. The collected urine is then tested for heavy metals. This approach helps uncover hidden heavy metals in the body that might not be detected in standard tests.

3. **Other Laboratory Tests** Additional tests, such as a complete blood count, liver function tests, and kidney function tests, can also provide insights into the body’s capacity to manage toxins and the effectiveness of chelation therapy. These tests help identify any potential strain or damage to organs caused by heavy metals.

It’s crucial to conduct all medical procedures and tests under the supervision of a qualified healthcare provider to ensure they are performed safely and accurately.

Kidney Function

Several ingredients found in modern chelation support products may have beneficial effects.

EDTA is a chelating agent known for its ability to bind to heavy metals. It can potentially aid in their removal, reducing the toxic burden on the kidneys. A study published in Biomedical Research International suggested the potential benefit of EDTA.

Chlorella Algae, known for its detoxifying properties, has also shown promise in helping renal function. Specifically, a study in the Journal of Medicinal Food suggested that Chlorella might improve renal function in dialysis patients by reducing the absorption of toxic substances in the intestines.

Modified Citrus Pectin, a specialized form of pectin, may be able to bind to and facilitate the excretion of a range of toxins, including heavy metals. This could potentially reduce the burden these toxins place on the kidneys, as highlighted in a study published in Phytotherapy Research.

Brain Detox

Several unique ingredients could support brain health and function. For instance, EDTA might reduce the harmful effects of heavy metals on the brain by helping remove them. Accumulated heavy metals are linked to neurological conditions such as Alzheimer’s disease.

A review in the Journal of Alzheimer’s Disease pointed out the potential benefits of chelation therapy for Alzheimer’s.

Alpha Lipoic Acid, an antioxidant, has been associated with potential benefits for the brain. A review in CNS & Neurological Disorders – Drug Targets indicated that Alpha Lipoic Acid might protect the brain in conditions like multiple sclerosis and Alzheimer’s disease.

Shilajit, an ancient remedy from Ayurvedic tradition, has been credited with neuroprotective effects. A study published in the Journal of Ethnopharmacology found that Shilajit could enhance memory and cognitive functions in rats. This suggests it could benefit brain health.

Remember, while these findings are promising, they aren’t definitive proof of effectiveness. More studies, especially on humans, are needed to draw firm conclusions. Always check with a healthcare provider before starting any new supplement.

Liver Detox

The liver plays a key role in detoxification within the body. One of its main jobs is to filter out harmful substances from the bloodstream. When unhealthy heavy metals enter the bloodstream, it is the liver’s responsibility to help remove them, which can tax your system. Chelation therapy may support liver health by aiding in detoxification and reducing the overall toxic burden on the liver.

Here are some specifics on things that have been studied for their potential to support liver health:

  1. EDTA (Ethylene Diamine Tetraacetic Acid). As a chelating agent, EDTA binds to heavy metals and helps remove them from the body. This can potentially reduce the strain on the liver, which otherwise would have to work harder to remove these toxins. A study published in the Journal of Inorganic Biochemistry demonstrated the ability of EDTA to chelate cadmium and reduce its toxic effects in the liver, potentially preserving liver health 13.
  2. Milk Thistle Seed Powder. Milk thistle is known for its liver protective properties, which can protect the liver from damage. A review published in the Journal of Veterinary Internal Medicine reported that silymarin, an active compound in milk thistle, can help protect the liver from toxins, including certain heavy metals 14.
  3. NAC (N-Acetyl Cysteine). NAC is a powerful and well-known antioxidant that can help to neutralize harmful free radicals in the body. A World Journal of Gastroenterology study reported that NAC may help reduce liver damage caused by various toxic substances, including heavy metals 15.

Amazing Chelation Supplements: A Preventive Measure for Health, Not a Cure for Severe Disease

Chelation therapy can often be misunderstood when taken via oral capsules. It is preventative, not a panacea or cure-all. It is not capable of curing severe diseases and chronic health conditions.

Oral chelation blends, like Chelanox, are preventive measures that aim to reduce the body’s toxic load. They help support overall health and potentially reduce the risk of specific health issues.

How They Work

Chelation works by binding to toxic metals in the body and aiding in their removal. These toxins, including heavy metals like lead, mercury, and arsenic, can build up over time. This can be due to various factors, such as environmental pollution. Consumption of certain foods and exposure to some types of industrial work can also come into play. Over time, this toxic load can contribute to many health issues, including cardiovascular disease, neurological disorders, and kidney damage. By helping to reduce this toxic load, chelation can potentially support overall health and wellness.

Ingredients in chelation products like EDTA, Chlorella Algae, and Modified Citrus Pectin have been shown in studies to bind to toxins. This potentially aids their removal from the body. This does not mean they can cure diseases caused by these toxins, but they may help reduce the risk or severity of such diseases by limiting the body’s exposure to these harmful substances.

Chelation can’t replace conventional treatments for severe diseases. Chelation supplements are not likely to reverse these conditions or act as a standalone cure for individuals with significant health conditions like late-stage cardiovascular disease, advanced kidney disease, or serious neurological disorders.

Severe diseases typically require comprehensive treatment plans overseen by healthcare professionals, including medication, lifestyle changes, and in some cases, surgical interventions.


Chelating ingredients shine in preventive health care. They aid in toxin management, helping overall health and reducing disease risks. Combined with a healthy lifestyle, they form a strong disease prevention strategy. Chelation can be a valuable preventive tool, not a cure. Always consult a healthcare provider before starting any new supplement, especially if you have health conditions or take other medications. This ensures safety and suitability.