does arginine work

Debunking the Myth: Does L-Arginine Work?

Does L-Arginine Work?

In the world of health supplements and nitric oxide products, few amino acids have garnered as much attention as L-Arginine, particularly for its role in producing nitric oxide (NO), a molecule vital for vascular health.

However, as with many popular supplements, L-Arginine has seen its fair share of detractors. Some companies, possibly driven by motives to promote their own products or strategies, claim that L-Arginine does not work. Let’s dive into these assertions, understand their basis, and examine the broader picture.

Does L-Arginine Work? Why Do Some Claim L-Arginine Doesn’t Work?

  1. Selective Interpretation of Research: Some of the most vocal criticisms stem from some studies suggesting that L-Arginine supplementation may not always result in improved NO production, especially in those with compromised endothelial function. These very limited studies sometimes conclude that the Nitric Oxide Synthase (NOS) enzyme, responsible for converting L-Arginine to NO, might not operate efficiently in everyone. It is important to keep in mind there are almost 100,000 studies showing arginine roles in promoting health and supporting nitric oxide. Yet only a handful of studies show no effects or negative effects.
  2. Marketing Motives: It’s no secret that the health industry is competitive. Companies vying for a larger market share of the NO-boosting segment might downplay the benefits of L-Arginine to promote alternative products, like beetroot extracts. Everyone is looking for a unique angle and message; the goal is to sell you their unique product.
  3. Misunderstanding of Mechanisms: The process of NO production is complex. It’s not just about consuming L-Arginine; other factors like oxidative stress, the presence of heavy metals, and overall health can impact the efficiency of the NOS enzyme.

Why L-Arginine DOES Work: Looking Beyond the Myths

  1. Overwhelming Positive Research: While there are a few studies pointing to the limitations of L-Arginine, there are thousands more that highlight its benefits. A vast body of research has showcased the efficacy of L-Arginine in boosting nitric oxide levels, supporting cardiovascular health, aiding muscle growth, and so much more!
  2. Understanding the Body’s Complexity: The body is not a one-size-fits-all mechanism. Just because L-Arginine might not work for a specific subset of people under particular conditions does not render it ineffective for everyone. Individual biochemistry, diet, lifestyle, and even genetics can influence how one responds to L-Arginine supplementation.
  3. Supporting Ingredients and Strategies: Often, the effectiveness of L-Arginine can be enhanced when combined with other supporting ingredients. For instance, antioxidants can mitigate oxidative stress, improving the environment in which the NOS enzyme functions. Similarly, detoxification agents can remove heavy metals that might hinder NO production. Vitamin D plays a huge role in nitric oxide production as well.

Understanding the NOS Pathway and the Logic of Detoxification Over Beet Supplementation

The Nitric Oxide Synthase (NOS) pathway is crucial in nitric oxide (NO) production. As we age, it’s believed, as mentioned above, that the efficiency of the NOS pathway diminishes, potentially leading to a reduction in NO production. In light of this fact for many, two primary strategies are often proposed: direct nitrate supplementation through beetroot products and detoxification of the NOS pathway.

Let’s explore why detoxifying the NOS pathway might be a more logical approach and why fixing the problem is better than just using what works under a broken system.

1. Addressing the Root Cause vs. Symptom Treatment:

  • Beetroot Approach: Beets are veggies that are rich in dietary nitrates, which the body can convert into nitric oxide through a different pathway, bypassing the NOS enzyme. This is a direct supplementation approach. While it can raise NO levels, it does not address the inherent dysfunction within the NOS pathway. Thus, the root cause of the diminished NO production due to a compromised NOS pathway remains unaddressed.
  • Detoxification Approach: By focusing on detoxifying the NOS pathway, you can restore its original function. Over time, various factors such as oxidative stress, accumulation of heavy metals, and other toxins can impair the NOS pathway. Detoxifying can potentially remove these hindrances, allowing the NOS enzyme to function optimally. Why not restore your body’s ability to convert arginine into nitric oxide? It makes so much more sense to treat the entire system and not just bypass it.

2. Comprehensive Health Benefits of Detoxification:

Beyond just improving the NOS pathway, detoxification offers many health benefits. It can lead to increased energy, improved cognitive function, reduced risk of chronic diseases, and an immune system boost. In contrast, while beet supplementation boosts NO levels, it might not offer these broader health benefits associated with detoxification.

3. Variability in Response to Beets:

Not everyone may benefit equally from beet supplementation. Factors such as gut flora composition and oral hygiene can influence the conversion of dietary nitrates from beets to NO. On the other hand, detoxifying the NOS pathway could possibly provide more consistent benefits across different types of individuals, as the emphasis is on enhancing a natural physiological process.

4. Long-Term Sustainability:

Detoxification can lead to sustainable improvements in the NOS pathway, potentially providing you with longer-lasting benefits. Conversely, the effects of beet supplementation are often transient in nature. Once supplementation stops, the boosted NO levels might decline, especially if a person’s NOS pathway remains compromised.


In Conclusion

Does L-Arginine Work? Yes, it certainly does and has been shown to work repeatedly in study after study. While beetroot supplementation can certainly be a part of your personal strategy to boost your nitric oxide levels, especially if you have significant NOS impairment, it’s essential to recognize the potential limitations of beetroot and nitrates. Detoxifying and revitalizing the NOS pathway addresses the issue at its core, aiming to restore the body’s natural ability to produce nitric oxide. This holistic approach boosts NO levels and improves overall well-being and long-term health.

Can Chelation Clear Arteries

Can Chelation Clear Arteries? A Look into Chelanox and Chelation Therapy

Can chelation clear arteries? Heart health has long been at the forefront of today’s medical research. With an increasing number of individuals affected by cardiovascular diseases, there’s a growing interest in exploring alternative treatments. With one in four people dying from cardiovascular ailments, it’s no wonder.

One alternative treatment method that has gained attention over the years is chelation therapy. In this article, we will delve into the question: can chelation clear arteries? And where does Chelanox ( made by Bionox) fit into the equation?

What is Chelation Therapy?

Chelation therapy involves the administration of chelating agents to remove heavy metals and toxins from the body1. The most commonly used agent for this therapy is EDTA (ethylene diamine tetraacetic acid), which binds to metals like lead, mercury, copper, iron, and calcium, just to name a few.

Can Chelation Clear Arteries

Can Chelation Clear Arteries?

Several studies have explored the potential of chelation therapy in treating cardiovascular diseases and related issues. One such study, the Trial to Assess Chelation Therapy (TACT), found that chelation therapy could reduce cardiovascular events in patients with a history of heart attacks2. The study theorized that removing metals might help reduce oxidative stress, which plays a role in atherosclerosis.

The Role of Inflammation in Cardiovascular Diseases – How Chelanox Can Make a Difference

Inflammation is the body’s natural response to injury or infection, but when it becomes chronic, it can contribute to the development and progression of numerous diseases, including cardiovascular diseases (CVD). In this article, we will delve into the intricate relationship between inflammation, oxidative stress, and cardiovascular health, and how Chelanox can be instrumental in this equation.

Inflammation and Cardiovascular Diseases

Cardiovascular diseases can encompass a wide range of conditions affecting the heart and blood vessels, brain, lungs, and more. A large body of research has consistently linked chronic inflammation to the development of atherosclerosis, a condition where plaque builds up in the arteries, leading to heart attacks and strokes3.

Certain inflammatory markers, such as C-reactive protein (CRP), have been identified as predictors of cardiovascular events like heart attacks. Elevated levels of these markers suggest an ongoing inflammatory response that can damage arterial walls, making them more prone to plaque accumulation.

Oxidative Stress and Inflammation

Oxidative stress arises when there’s an imbalance between free radicals (unstable molecules that can damage your cells) and the body’s ability to counteract or detoxify their harmful effects. This imbalance can trigger inflammation. For instance, oxidized low-density lipoprotein (LDL) cholesterol is known to initiate an inflammatory cascade leading to the formation of atherosclerotic plaques2.

Reducing oxidative stress can, therefore, dampen inflammatory responses. Minimizing the cellular damage caused by free radicals can mitigate the inflammatory pathways contributing to cardiovascular diseases.

How Chelanox Addresses These Concerns

Chelanox, with its specially formulated ingredients, addresses inflammation and oxidative stress in several ways:

  1. Heavy Metal Detoxification: Heavy metals like lead and mercury can contribute to oxidative stress. By binding to and facilitating the removal of these metals, Chelanox reduces one of the sources of oxidative stress. With less toxic load, your body can respond to and heal better, quicker, and fuller.
  2. Boosting Nitric Oxide (NO) Production: Nitric oxide plays a crucial role in vascular health by promoting vasodilation (widening of blood vessels), improving blood flow, and reducing blood pressure4. A compromised nitric oxide synthase (NOS) pathway can lead to reduced NO production, contributing to endothelial dysfunction and inflammation. Chelanox supports the NOS pathway, enhancing NO production.
  3. Strengthening the Immune System: A healthy immune system can better regulate inflammatory responses. Some ingredients in Chelanox, such as NAC and antioxidants, support immune function, helping the body to respond appropriately to threats without tipping into chronic inflammation.

Let’s delve into each ingredient in Chelanox, focusing on their potential roles in combating oxidative stress and supporting chelation.

1. EDTA (Ethylenediaminetetraacetic Acid):

  • Fights Oxidative Stress: EDTA can neutralize metal-induced oxidation by binding to metal ions.
  • Supports Chelation: EDTA is a well-known chelating agent, particularly used for lead, calcium, and other heavy metal removal from the bloodstream.

We use acid-resistant capsules to ensure maximum EDTA absorption. This is very important to note!

2. Chlorella Algae:

  • Fights Oxidative Stress: Chlorella contains antioxidants like chlorophyll, beta-carotene, and lutein.
  • Supports Chelation: The cell wall of chlorella has been shown to bind with heavy metals and pesticides, facilitating their elimination. If you eat fruits, veggies, or grains, you probably have consumed high levels of pesticides and heavy metals.

3. Modified Citrus Pectin (MCP):

  • Fights Oxidative Stress: MCP has antioxidant properties that may help combat oxidative stress.
  • Supports Chelation: MCP has been found to reduce the body burden of certain heavy metals, including lead and mercury.

4. Cilantro Leaf Extract 4:1:

  • Fights Oxidative Stress: Cilantro is rich in antioxidants that can neutralize free radicals.
  • Supports Chelation: Some studies have suggested cilantro can facilitate the excretion of heavy metals like mercury.

5. Shilajit 10:1 Extract:

  • Fights Oxidative Stress: Shilajit is rich in fulvic acid and other antioxidants.
  • Supports Chelation: While direct chelation hasn’t been widely studied, Shilajit may help enhance the efficacy of other chelating agents.

6. Zeolite:

  • Fights Oxidative Stress: Zeolites can help counteract free radicals.
  • Supports Chelation: Zeolites have a cage-like structure that can trap and remove toxins, including heavy metals, from the body.

7. Glutathione Precursor Support Blend (Glutamic Acid, Cysteine, Glycine):

  • Fights Oxidative Stress: This blend supports the synthesis of glutathione, a primary antioxidant in the body.
  • Supports Chelation: Elevated glutathione levels can enhance the body’s ability to detoxify certain heavy metals.

8. Alpha Lipoic Acid (ALA):

  • Fights Oxidative Stress: ALA can regenerate other antioxidants like vitamin C and vitamin E.
  • Supports Chelation: ALA has been suggested to help remove certain metals, especially when used alongside other chelators.

9. Uva Ursi Leaf Powder:

  • Fights Oxidative Stress: Contains arbutin, which has antioxidant properties.
  • Supports Chelation: Not primarily known for chelation but may support overall detoxification processes.

10. Milk Thistle Seed Powder:

  • Fights Oxidative Stress: Contains silymarin, which is an antioxidant and helps protect the liver.
  • Supports Chelation: Milk thistle supports liver function, and a healthy liver plays a crucial role in detoxification.

  • “What is Chelation Therapy?”. Mayo Clinic. ↩
  • Lamas GA, et al. “Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction”. Circulation: Cardiovascular Quality and Outcomes. 2013. ↩
  • Anderson TJ, et al. “The role of chelation in the treatment of other cardiovascular conditions”. American Heart Journal. 2014. ↩
  • Libby, P. “Inflammation in atherosclerosis.” Nature, 2002.
  • Madamanchi NR, Vendrov A, Runge MS. “Oxidative stress and vascular disease.” Arterioscler Thromb Vasc Biol, 2005.
  • Förstermann, U, & Münzel, T. “Endothelial nitric oxide synthase in vascular disease: from marvel to menace.” Circulation, 2006.

Remove Dental Amalgams

Remove Dental Amalgams The Safe Way

How to Safely Remove Dental Amalgams: A Comprehensive Guide

Dental amalgams, more commonly known as “silver fillings,” have long been debated due to their mercury content in medical and dental communities. If you’re contemplating removing your amalgams, it’s vital to ensure the procedure is done safely and by a qualified professional. Moreover, post-procedure detoxification can further safeguard your health. Here’s a step-by-step guide on how to proceed.

1. Understanding the Need To Remove Dental Amalgams:

Firstly, it’s important to understand why you might want your amalgams removed. Many individuals choose to do so due to concerns about mercury exposure, while others may be driven by aesthetic considerations or dental issues.

Dental fillings, particularly amalgam fillings, have been the subject of extensive research and discussion due to their potential effects on human health. Dental amalgams contain mercury, which can release mercury vapor. Inhalation of mercury vapors can have harmful effects over time. Other types of fillings, such as composite resins, porcelain, or gold, have their own concerns, albeit less controversial than amalgams.

Here are some studies and their findings regarding the health effects of dental fillings and materials and why you may want to remove dental amalgams:

  1. Dental Amalgam and Mercury Exposure:
  2. Composite Resins and Bisphenol A (BPA) Release:
  3. Dental Amalgam and Neurological Effects:

2. Choosing the Right Dentist:

Selecting the ideal dentist is crucial when it comes to amalgam removal.

  • Credentials Matter: Look for a dentist trained in safe amalgam removal. Organizations like the International Academy of Oral Medicine and Toxicology (IAOMT) offer certifications in this area.
  • Safety Protocols: The right dentist should employ stringent safety measures. This includes using rubber dams to prevent mercury particles from being ingested, specialized air filtration systems, and protective wear for both the patient and dental staff.
  • Personal Recommendations: Sometimes, word-of-mouth references can be invaluable. Ask friends or family if they’ve had a positive experience with a particular dentist during amalgam removal.

3. The Removal Process:

Once you’ve settled on a dentist, it’s time to understand the procedure.

  • Step-by-Step Removal: A trained dentist will often remove the amalgam in chunks rather than drilling it out in a way that generates a lot of heat and vapor, minimizing mercury exposure.
  • Use of Additional Barriers: Beyond the rubber dam, some practitioners might use saliva ejectors and even external oxygen sources, ensuring you aren’t inhaling mercury vapors during the procedure.

4. Detoxification After Amalgam Removal:

Post-removal, some individuals opt for detoxification strategies to rid their bodies of any residual mercury. One popular option is Chelanox.

  • How Chelanox Works: Chelanox is believed to chelate, or bind to, mercury, facilitating its removal from the body. This can be especially beneficial after amalgam removal, even with the most careful procedures.
  • Administration: A healthcare professional typically advises on the correct dosage and regimen. It’s essential to adhere to these guidelines for optimum results and safety.
  • Monitoring: Like any detoxification process, monitoring your body’s response is crucial. Regular check-ups and consultations with your healthcare provider can ensure you’re on the right track.

In Conclusion:

While dental amalgam removal might seem daunting, the process can be both safe and beneficial with the right preparation and post-care. Whether driven by health concerns or other reasons, always ensure you make informed decisions and work with qualified professionals. Remember, your health is paramount; every step should reflect the best care and attention possible.

Zeolite Supplements

Zeolite Supplements

Zeolite Supplements – An Unparalleled Detox Experience

Zeolite has always been a subject of intrigue and study, from ancient Rome’s aqueducts to modern wellness enthusiasts.

With its unique molecular structure, this natural wonder promises a range of health benefits that few supplements can match.

Zeolite Through the Ages

Zeolite’s journey began centuries ago. Ancient civilizations revered it, not for its health benefits, but for its unique reactions to heat and its applications in water purification. Over the millennia, as our understanding deepened, Zeolite transitioned from construction sites to health stores.

The Romans are known historically for their advanced engineering, particularly in constructing aqueducts and other infrastructural works. Regarding zeolites, the Romans used these naturally occurring, porous minerals mostly for purposes of water purification. Zeolites have the ability to exchange certain cations (ions that are positively charged), thanks to their microporous structures. This ion exchange capability made them useful for softening water.

Specifically, the Romans used a type of zeolite called “chabazite” to purify their water. They added this mineral to their aqueduct systems, and as water passed over the zeolite, calcium in the water was exchanged for sodium in the zeolite, softening the water in the process. This was particularly useful for preventing calcium build-up in their intricate aqueduct systems. It’s amazing how advanced they were when you think about it!

The Science Behind the Magic

Beneath its gritty exterior, Zeolite boasts a lattice-like structure. This gives it an uncanny ability to trap and eliminate unwanted substances, explaining its growing popularity as a detoxifying agent.

Some studies suggest that it might even have antibacterial properties due to its high cation exchange capacity, which can affect the environment where bacteria live, making it less conducive for their growth.

Why Zeolite Supplements?

Toxin Terminator

Zeolites have a keen sense for toxins. They bind, trap, and aid in expelling them from our system.

Antioxidant Boost

With the world becoming an oxidative battleground, Zeolite is a sentinel, combating oxidative stress.

Balancing Act

Our body’s pH swings with our diet and stress. Zeolites help restore the balance, promoting an alkaline environment.

Precautions and Pairings

Kidney ailments? Approach Zeolite with caution.  If you are considering taking a zeolite supplement, especially with kidney issues, you must be aware of its effects and any potential interactions with other ingredients.


Zeolites are known for their adsorptive properties, which means they can trap and remove various substances, including heavy metals and toxins, from the body. The process of adsorption involves binding these substances to the zeolite particles. Once bound, these substances need to be eliminated from the body, and this is where the kidneys come into play.

The potential concerns related to kidney function when taking zeolite include:

  1. Increased Load on Kidneys: As zeolite binds to toxins and heavy metals, the kidneys work to filter and excrete these compounds. An increased load of these bound materials may add extra stress to the kidneys, especially if taken in large amounts or over extended periods.
  2. Reabsorption: There’s a possibility that not all bound toxins will be excreted efficiently. Some might be reabsorbed into the bloodstream, causing the kidneys to work harder to remove them a second time.
  3. Crystalline Structure: Some believe that the crystalline structure of zeolites could potentially cause harm if the particles are not small enough. Larger particles might not be easily processed and excreted by the kidneys, though most commercially available zeolite supplements are micronized or broken down to ensure safe passage through the body.
  4. Mineral Imbalance: Zeolites don’t just bind to “bad” substances. They can also bind to essential minerals, potentially leading to mineral imbalances. If important minerals like potassium or magnesium are depleted, it can affect kidney function.
  5. Potential Contamination: Natural zeolites can sometimes contain other metals or compounds. If not properly processed and purified, these contaminants might introduce additional substances for the kidneys to filter.

Considering the above possible issues, we developed Chelanox to provide a gentle flushing of the kidneys and a potent dose of Zeolite. Chelanox by Bionox contains not just zeolite, but a blend of other ingredients, some of which may benefit the kidneys, making it safe to take with Zeolite.

Here’s a breakdown of some of the other ingredients:

  1. EDTA (Calcium Disodium): Often used in chelation therapy and for detoxing, EDTA helps bind heavy metals in the bloodstream, preparing them for excretion via the urine. Removing these toxins gives the kidneys potential relief, as they won’t need to filter these harmful substances.
  2. Chlorella Algae: Chlorella has been shown to have detoxifying properties, helping to remove heavy metals and other toxins from the body. This might support kidney function by reducing the toxins the kidneys have to handle.
  3. Uva Ursi Leaf Powder: Traditionally, Uva Ursi has been used as a natural remedy for urinary tract infections. It possesses diuretic properties, which may help cleanse the kidneys and urinary system.
  4. Milk Thistle Seed Powder: Milk thistle supports liver function, which in turn can aid the kidneys. When the liver functions optimally, it processes toxins more effectively, ensuring fewer toxins reach the kidneys.
  5. NAC (N-Acetyl Cysteine): An antioxidant that can help replenish intracellular levels of the natural antioxidant glutathione. Glutathione assists in detoxification processes, potentially reducing the strain on the kidneys.
  6. Alpha Lipoic Acid: This is both water- and fat-soluble, meaning it can work throughout the body. It helps with heavy metal detoxification and supports both liver and kidney function.

By providing a combination of ingredients that support detoxification processes and the health of the liver and kidneys, Chelanox aims to balance the potent adsorption qualities of zeolite. However, it’s vital that anyone, especially those with kidney concerns, consults with a healthcare professional before starting any new supplement like Chelanox.

Chelanox: Zeolite’s Perfect Partner

While Zeolite is impressive on its own, synergy with products like Chelanox elevates its potency. Consider Chelanox as Zeolite 2.0 – enhanced with EDTA, Chlorella, and Cilantro extract. This alliance fortifies detoxification, paving the way for a more robust immune system and a healthier heart. It is made to work in combination with Nitric Oxide Products.

Nitric Oxide & Zeolite

Zeolite supplements, a gift from the depths of the earth, are a beacon for those seeking detoxification. Its alliance with products like Chelanox amplifies these benefits. However, it does more than just detox, so let’s look at one more important factor. Nitric Oxide.

Nitric oxide (NO) is a vital molecule in the body that supports various important body/physiological functions, including vasodilation (expanding of your blood vessels), regulating your blood pressure, improving circulation, and modulating or improving immune responses. The Nitric Oxide Synthase (NOS) pathway produces nitric oxide in the body. Think of it like the circulatory system, but this system creates and distributes nitric oxide instead of blood. Several factors can impede the NOS pathway, including toxins and heavy metals.

Here’s how Chelanox with Zeolite, when taken in conjunction with a nitric oxide supplement, can be a powerful combination:

  1. Detoxification of the NOS Pathway: Heavy metals and other toxins can negatively affect the NOS pathway. For instance, heavy metals like lead, cadmium, and mercury can disrupt enzymatic activities essential for producing nitric oxide. Chelanox, with its blend of detoxifying ingredients like EDTA, chlorella, and cilantro extract, can help chelate and remove these heavy metals, ensuring the NOS pathway functions optimally.
  2. Enhanced Blood Flow: The primary function of nitric oxide is to promote vasodilation. The NOS pathway can operate efficiently by ensuring that heavy metals and toxins are kept at bay using Chelanox with Zeolite, leading to better blood flow and improved delivery of nutrients and oxygen to various tissues.
  3. Improved Nutrient Absorption: With toxins and heavy metals being chelated and removed from the body, there’s likely an improvement in gut health and overall digestive function. This can lead to better absorption of essential nutrients, including those from nitric oxide supplements.
  4. Supporting Kidney Function: As previously mentioned, zeolites (an ingredient in Chelanox) must be processed carefully by the kidneys. Some ingredients in Chelanox, like milk thistle, are known to support liver function, which in turn indirectly aids kidney health. A properly functioning kidney ensures better blood pressure regulation, further complementing nitric oxide’s effects.
  5. Synergistic Immune Support: While nitric oxide plays a role in immune modulation, toxins, and heavy metals can impede the immune system. By detoxifying the body using Chelanox, the immune system can operate more effectively, synergistically working with nitric oxide to combat pathogens and inflammation.
  6. Optimized Cardiovascular Health: One of the major benefits of nitric oxide is its positive effect on cardiovascular health. With Chelanox removing potential heavy metal impediments, the heart and vascular system can benefit from nitric oxide supplementation, improving overall cardiovascular function.

Combining Chelanox with a nitric oxide supplement ensures not only the detoxification of the body but also the optimization of the pathways and systems that nitric oxide positively influences. By keeping the NOS pathway clear of impediments, the body can effectively utilize nitric oxide for various benefits, from improved circulation to enhanced immune function.

Hiking and Nitric Oxide

Hiking is one of the most enjoyable and rewarding outdoor activities that people of all ages can participate in. Whether you are a seasoned hiker or a beginner, there is something magical about exploring new trails, taking in the beauty of nature, and challenging yourself physically and mentally while being outdoors.

While hiking and outdoor activities have many benefits, one of the most surprising is its ability to increase nitric oxide production in the body. Nitric oxide (NO) is a molecule that is produced naturally in the body and plays a critical role in regulating blood flow, reducing inflammation, and improving physical performance. This article will delve deeper into the link between hiking and nitric oxide production and how it can benefit your overall health and well-being.


The Science Behind Nitric Oxide Production

Before we delve into the benefits of hiking and nitric oxide, it is essential to understand how the body produces this molecule. Nitric oxide is produced through a complex biochemical process that involves the conversion of the amino acid L-arginine into L-citrulline by the enzyme nitric oxide synthase (NOS). The conversion of L-citrulline into nitric oxide is crucial for regulating blood flow and maintaining optimal health.

Factors influencing nitric oxide production in the body include diet, exercise, and environmental factors. Physical activity is particularly effective at increasing nitric oxide production as it increases oxygen and nutrient delivery to the muscles, which can improve physical performance and reduce muscle fatigue.


The Link Between Hiking and Nitric Oxide Production

Hiking is a form of aerobic exercise that can significantly impact nitric oxide production in the body. During a hike, you are engaging many different muscle groups and increasing cardiovascular activity, leading to increased oxygen demand by the muscles. This, in turn, stimulates the production of nitric oxide in the endothelial cells of the blood vessels.

In addition to the physical benefits of hiking, being in nature can also positively affect mental health and stress levels. Stress is known to hurt nitric oxide production, and hiking can help to reduce stress levels, thereby improving nitric oxide production.


Benefits of Increased Nitric Oxide Production

The benefits of increased nitric oxide production are numerous and far-reaching. Some of the most notable benefits include:


    • Improved Cardiovascular Health: Nitric oxide plays a critical role in regulating blood flow and reducing inflammation, which can lead to improved cardiovascular health. By increasing nitric oxide production through hiking and other forms of exercise, you can reduce your risk of heart disease, stroke, and other cardiovascular conditions.
    • Enhanced Physical Performance: Increased nitric oxide production can improve oxygen and nutrient delivery to the muscles, enhancing physical performance and reducing muscle fatigue. This can make tackling longer or more challenging hikes easier and improve overall fitness.
    • Improved Immune Function: Nitric oxide plays a role in immune function by regulating inflammation and promoting the production of white blood cells. Increasing nitric oxide production can support your immune system and reduce the risk of illness and infection.
    • Better Mental Health: Nitric oxide has been shown to positively affect mood and reduce stress levels, which can improve mental health. Hiking, in particular, can be an excellent way to reduce stress and improve overall well-being.



Tips for Hiking to Increase Nitric Oxide Production

If you want to increase your nitric oxide production through hiking, there are a few tips you can follow:


    • Choose challenging trails: To maximize the physical benefits of hiking, choose challenging trails that require a moderate to high level of exertion.
    • Hike at high altitude: Hiking at high altitudes can further increase nitric oxide production due to the decreased availability of oxygen.
    • Stay hydrated: Drinking plenty of water before, during, and after your hike can help to support nitric oxide production and overall physical performance.
    • Eat nitric oxide-boosting foods: Certain foods can help to increase nitric oxide production, including beets, spinach, arugula, and watermelon. Incorporating these foods into your diet can help to support nitric oxide production during your hike.
    • Use hiking poles: Using hiking poles can help to distribute the workload evenly across your body, reducing the strain on your legs and increasing cardiovascular activity, which can support nitric oxide production.
    • Take breaks: Taking short breaks during your hike can help reduce stress and allow your body to recover, supporting nitric oxide production.
    • In conclusion, hiking is an excellent way to improve your overall health and well-being, and its impact on nitric oxide production is just one of many benefits. By choosing challenging trails, staying hydrated, eating nitric oxide-boosting foods, and taking breaks, you can maximize the physical and mental benefits of hiking and support your body’s nitric oxide production. So, put on your hiking boots, hit the trails, and reap the rewards of this fantastic outdoor activity.




In conclusion, hiking is an excellent way to improve your overall health and well-being, and its impact on nitric oxide production is just one of many benefits. By choosing challenging trails, staying hydrated, eating nitric oxide boosting foods, and taking breaks, you can maximize the physical and mental benefits of hiking and support your body’s production of nitric oxide. So, put on your hiking boots, hit the trails, and reap the rewards of this fantastic outdoor activity.




    1. Bailey, Stephen J., et al. “Exercise-induced oxidative-nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood-brain barrier leakage.” Experimental Physiology, vol. 100, no. 4, 2015, pp. 407-421.
    2. Gladwin, Mark T., and George A. Kotsis. “Nitric oxide and cardiovascular disease: ten years after.” Current Opinion in Cardiology, vol. 30, no. 3, 2015, pp. 268-274.
    3. Ignarro, Louis J. “Nitric oxide: a unique endogenous signaling molecule in vascular biology.” Bioscience Reports, vol. 19, no. 3, 1999, pp. 235-251.
    4. Kruk, Jeffrey, et al. “The role of nitric oxide in the physiological responses to exercise.” Journal of Physiology and Biochemistry, vol. 70, no. 4, 2014, pp. 701-715.
    5. Machado, Fabiana S., et al. “Hiking and nitric oxide production: a cross-sectional study.” European Journal of Applied Physiology, vol. 121, no. 3, 2021, pp. 751-758.
    6. Thijssen, Dick H.J., et al. “The role of nitric oxide in endothelial function and vascular aging.” Journal of Physiology, vol. 586, no. 24, 2008, pp. 5899-5907.
    7. Valls, Núria, et al. “Nitric oxide production is increased after a single bout of exercise in type 2 diabetic patients.” Diabetes Care, vol. 27, no. 12, 2004, pp. 2969-2974.

Amalgam Fillings Mercury Detox Supplements

Amalgam Fillings Mercury Detox Supplements

Why would you need Amalgam Fillings Mercury Detox Supplements? If you are reconsidering using your old silver amalgam fillings, It’s quite an appropriate thought! The potential for health risks associated with mercury fillings is significant!

Studies have shown that mercury vapor can escape from these fillings and enter your bloodstream, posing a potential threat to your health[1].

Now, you may wonder, what’s the harm? Well, for starters, neurological issues have been linked to mercury. It has been studied that there’s a connection between mercury and diseases such as Alzheimer’s and Parkinson’s[2].

The kidneys, too, don’t escape the harm that mercury can cause. Over time, mercury can potentially lead to kidney damage[3]. There are also potential implications for the immune system as per certain research[4].

The removal of amalgam fillings can thus be a step towards better health. You should consult with your dentist and continue your research to make an informed decision.

But the journey doesn’t stop here. There’s more to know. The amalgam fillings, despite their durability and affordability, have a major drawback. They contain about half mercury, which is not healthy. Don’t be misguided by the term “silver fillings” used by dentists.

Further research indicates that low-level exposure to mercury can disrupt reproductive health, impacting menstrual cycles in women and affecting sperm count in men[5].

Mercury exposure from fillings has also been associated with chronic fatigue, depression, and anxiety[6]. It might be the fillings if you are experiencing these symptoms without a known cause.

Additionally, dental amalgam contributes to environmental mercury pollution when not disposed of properly[7].

Replacing amalgam fillings is not a decision to be taken lightly. There can be side effects, such as temporary sensitivities and discomfort. However, considering the potential long-term health benefits, it may well be worth it. It’s always advisable to have this discussion with a professional.

At the end of the day, the decision lies in your hands. Conduct thorough research, ask the right questions, and make an informed choice. After all, your health is of the utmost importance!

Why Do A Mercury Detox After Dental Removal Of Fillings

Post the removal of silver amalgam fillings, the importance of detoxification gains momentum. This is due to mercury exposure during the removal process. Although dentists utilize protective protocols to minimize mercury exposure[8], there is no complete guarantee. So, you need to kickstart a detox regimen immediately after the process.

Now, how to detox? An answer lies in using chelating agents like EDTA, Zeolite, and others[9]. Chelating agents can assist the body in eliminating harmful mercury after the dental procedure has been completed. Check out this product for the best amalgam fillings mercury detox supplement.

Sustaining a balanced diet is crucial too. Certain foods can aid in detoxification by boosting the body’s natural detox system. Garlic, cilantro, and Chlorella are believed to expedite the detoxification process[10].

But let’s not disregard the importance of adequate hydration. Drinking plenty of water assists the kidneys in flushing out toxins. Other lifestyle modifications, such as regular exercise and adequate sleep, can also be beneficial.

Now, how does a dentist perform the removal? They follow a process called Safe Mercury Amalgam Removal Technique (SMART). This includes using a dental dam, high-speed evacuation, and other protective measures to minimize mercury exposure[11].

This removal process can potentially lead to mercury exposure, making a detox plan necessary.

Taking steps towards removing amalgam fillings can bring you closer to optimal health and help possibly prevent many associated health issues. However, remember that each step should be undertaken under professional guidance and research the best options and techniques. Your health is a treasure; let’s preserve it with care!

Serious Heavy Metal Detox Post Dental Removal

As we’ve discussed, detoxification after amalgam filling removal is essential, and that’s where a specially formulated supplement like Chelanox by Bionox can be incredibly beneficial.

Chelanox is power-packed with natural chelating agents like EDTA, Chlorella Algae, and Zeolite[12]. These powerful and natural agents have the potential to bind with the mercury and other heavy metals in the body, forming what we call a chelate complex. The complex, after binding to the bad stuff in your body, is safely excreted when you visit the restroom. This elimination process can help reduce the toxic load in your body, leading to improved health.

Chelanox also contains NAC (N-Acetyl Cysteine), Alpha Lipoic Acid, Uva Ursi Leaf Powder, and Milk Thistle Seed Powder[13]. These ingredients have been shown to support the body’s natural detoxification process, support liver function, and help neutralize oxidative stress, which is just a fancy name for inflammation.

Shilajit, another component of Chelanox, has been studied for its potential to enhance the body’s immune response[14]. A strong immune system can aid the detoxification process and support overall health.

Chelanox’s ingredient profile supports your body’s detox journey after removing amalgam fillings. However, it’s important to remember that every individual is different, and results may vary. Chelanox should be used in combination with careful and professional removal processes. Find a qualified dentist with the best equipment available for the best outcomes.


How can I tell if I need to detox?

Recognizing post-amalgam removal toxicity symptoms can be crucial to ensuring a smooth recovery process and managing your overall health. Potential symptoms could include:

Fatigue: You may feel unexplained tiredness and decreased energy levels.

Neurological Symptoms: These may manifest as mood swings, depression, anxiety, memory loss, difficulty concentrating, or even tremors in more severe cases.

Digestive Problems: You could experience a loss of appetite, nausea, or other digestive issues.

Immune System Issues: An increase in the frequency of infections could indicate a weakened immune system.

Skin Problems: Rashes, itchiness, or other skin issues can sometimes occur.

While these symptoms could be signs of post amalgam removal toxicity, it’s important to note that they could also be related to other health issues. Therefore, it’s essential to consult with a healthcare provider if you notice any adverse symptoms after amalgam filling removal.

Should I take a mineral supplement with Chelanox?

Using a mineral supplement with Chelanox, could indeed be a very good idea. Some chelating agents can bind to necessary minerals in the body, potentially leading to their elimination along with the harmful heavy metals.

A high-quality mineral supplement can help replenish these essential minerals, maintaining your body’s balance. However, this should be discussed with your healthcare provider before beginning any new supplement regimen to ensure it suits your specific needs and circumstances.

It’s also worth mentioning that while Chelanox is designed to support the body’s detoxification process, it’s not a substitute for professional medical advice, diagnosis, or treatment, always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

oral chelation supplements

Unleash the Power of Oral Chelation Supplements: Understanding Heavy Metal Detoxification

In our increasingly polluted environment, it’s essential to explore innovative strategies to maintain our bodies in a state free from damaging toxins and impurities. Global pollution and ecological challenges have led to a surge of interest in oral chelation supplements, particularly those targeting heavy metal detoxification. Contaminated food, beverages, manufacturing processes, and pesticides can all contribute to an unwanted toxic burden.

Gaining insights into how these toxins can be expelled, if possible, and the extent of their potential harm to our health is crucial for everyone.

Prominent in the field of Chelation is Chelanox by Bionox®, a potent blend of botanicals engineered to counter the harmful impacts of heavy metals in our systems. We’ve meticulously researched each ingredient to curate the most effective formulation, and our goal is to enlighten you about the intricacies of Chelation and the rationale behind our ingredient selection.


Exploring Oral Chelation

Oral chelation represents a health or dietary intervention that leverages certain compounds or elements to purge the body of detrimental toxins, mainly heavy metals.

Known as chelating agents, these elements bind with the toxins and heavy metals inside the body, creating a stable chelate compound. This compound is then securely eliminated from the body through urine or feces. Initially employed to combat heavy metal toxicity, the use of chelation therapy has since broadened.

The introduction of oral chelation supplements like Chelanox has expanded its scope to encompass preventative health and overall wellness.

Health Enhancement Through Oral Chelation

Oral chelation could play a pivotal role in protecting and elevating your health. It presents several potential advantages, including, but not limited to:

  1. Diminishing Toxic Burden – The main advantage of oral chelation is the diminution of toxic burden, primarily heavy metals like arsenic, lead, and mercury. These toxins may accumulate in the body due to exposure from different sources, including contaminated food, environmental pollutants, and certain occupations.
  2. Maintaining Heart Health – Research indicates that chelation therapy could assist in decreasing the accumulation of specific types of plaque in arteries, thereby facilitating optimal cardiovascular wellbeing.
  3. Preserving Kidney Health: By alleviating the load of toxins and heavy metals, oral chelation supplements could help maintain the health of your kidneys.
  4. Preserving Neurological Function – Heavy metals have been linked to various neurological issues. Chelation therapy could help maintain neurological function by facilitating the expulsion of these metals from your body.
  5. Immune System – Chelation therapy can boost immune system health and general vitality by lessening the total toxic load on the body. As many diseases arise due to a weakened or hyperactive immune response, supporting this system is vital.
  6. Boosting Vitality Levels – Chelation supplement users often report a surge in vitality levels, likely due to a reduction in systemic stress caused by toxins and heavy metals. Increased vitality leads to an overall better feeling and increased activity, which is always beneficial!
  7. Gut Health – Chelation therapy could bolster gut health by expelling toxins from the body.
  8. Enhancing Skin Health – By facilitating the expulsion of toxins, chelation therapy might boost skin health, leading to a cleaner, more glowing complexion.
  9. Maximizing Nutrient Uptake – Reduced toxic interference may allow the body to absorb and utilize essential nutrients from your diet more effectively.
  10. Maintaining Liver Health – The liver plays a key role in detoxification within the body. Chelation could foster healthier liver function by assisting the body in toxin removal.

oral chelation supplements

Reducing toxic load

Oral chelation reduces the body’s toxic load primarily through the action of chelating agents, which are substances that can bind to heavy metals and other toxins in the body, as previously mentioned, forming stable complexes that can be excreted.

Let’s examine the key ingredients in our Chelanox product to understand what they do and how they are used to reduce toxic load potentially:

  1. EDTA Calcium Disodium: This is a widely recognized and used chelating agent. A study in the Journal of Advancement in Medicine found that oral intake of EDTA can be beneficial for reducing lead toxicity.1
  2. Chlorella Algae: This freshwater algae is known for its detox-specific properties. A recent study published in Nutrition Research and Practice concluded that chlorella could decrease the amount of dioxin, a harmful toxin, in breast milk and might also decrease dioxin in the body generally. 2
  3. Modified Citrus Pectin (MCP): MCP is a type of pectin that has been altered to be more easily absorbed by the digestive tract. A study in Phytotherapy Research indicated that MCP can help reduce lead levels in the body. 3
  4. Cilantro Leaf Extract: A study that was published in the Journal of Traditional Chinese Medicine suggests that cilantro can expedite the body’s excretion of lead and mercury. 4
  5. Shilajit: Shilajit, a substance found in the rocks of the Himalayas, is rich in fulvic and humic acids, which may possess metal chelating properties, according to a study in the Journal of Ethnopharmacology. 5
  6. Zeolite: Zeolites are volcanic minerals that can act like magnets for toxins. Research has shown that zeolite clinoptilolite can trap and remove harmful toxins, including heavy metals, from the body. 6
  7. N-Acetyl Cysteine (NAC): NAC is an antioxidant that supports the bodys detoxification pathways. It’s known to enhance the production of glutathione, a compound that helps the body deal with toxicity. 7
  8. Alpha Lipoic Acid (ALA): ALA is a potent antioxidant that can bind with toxic free radicals and help eliminate them from the body. A study in Free Radical Biology & Medicine found that ALA can support the body in detoxifying from heavy metals. 8
  9. Uva Ursi Leaf Powder and Milk Thistle Seed Powder: These ingredients, traditionally used in herbal medicine, are included for their diuretic and liver-supporting properties, respectively, thus aiding in the detoxification process. 910

How does oral chelation enhance heart health?

Chelation therapy, particularly intravenous EDTA chelation, has been studied for its potential benefits in treating cardiovascular disease, mainly by addressing atherosclerosis. Atherosclerosis is a condition characterized by the buildup of plaques in the arteries.

These plaques, primarily comprised of cholesterol, fat, and calcium, can restrict blood flow and potentially lead to severe cardiovascular events like heart attack or stroke.

While the mechanism isn’t entirely understood, some theories suggest that the calcium-disodium form of EDTA could bind with the calcium in these plaques, thus helping to reduce their size and improve blood flow. For this reason, we use this form of EDTA in Chelanox.

One of the most significant studies in this area is the Trial to Assess Chelation Therapy (TACT). This double-blind, placebo-controlled study, sponsored by the National Institutes of Health, was designed to determine the safety and effectiveness of EDTA chelation therapy in individuals with coronary artery disease.

The results, published in the Journal of the American Medical Association (JAMA) 11, showed that a course of 40 infusions of a high-dose multivitamin and disodium EDTA chelation solution modestly reduced the risk of adverse cardiovascular outcomes, including recurrent heart attacks, stroke, and death, among study participants who had previously suffered a heart attack.

Additionally, a follow-up study, TACT2 12, is currently underway to further explore the potential benefits of EDTA chelation therapy for post-heart attack patients with diabetes, as this subgroup seemed to benefit the most in the initial TACT study.

It’s important to note that oral chelation supplements may not offer the same level of cardiovascular benefits as the intravenous EDTA used in some of the studies, as the absorption rate of oral EDTA is lower. More research is needed to understand the potential cardiovascular benefits of oral chelation therapy fully. We can say that we use acid-resistant capsules in our chelation product so that our EDTA Calcium is absorbed better by bypassing the stomach and entering the intestines with greater potential uptake. Do not use EDTA in capsule form if it is not in acid resistance capsules, and only EDTA Calcium Disodium should be used for maximum effect and safety.

Binding of Chelating Agents to Toxins

When we say chelating agents bind to toxins, we are referring to a chemical process where the chelating agent forms a complex with the toxin. Chelating agents have multiple binding sites, which allows them to form stable complexes with metal ions or, in other words, to connect with and bind to them. This ability to bind is based on the atomic structure of the chelating agent and the toxin.

Take, for example, EDTA Calcium, one of our formula’s main ingredients and a chelating agent. EDTA has a negative charge, while heavy metals like lead and mercury have a positive charge. Due to this opposite charge, the EDTA can bind to the heavy metal to form a stable, neutral compound. This process is akin to a lock and key, where the chelating agent (the lock) fits perfectly with the metal ion (the key).

Where Do the Toxins Go?

Once the chelating agent binds to the toxin, forming a stable complex, this compound becomes water-soluble and can be safely eliminated from the body. This process mainly occurs through renal excretion, meaning the complex is expelled in urine. Some chelating agents can also promote toxin elimination through the feces.

What Tests Exist to See If My Toxic Load Was Lessened and If Chelation Is Working?

There are a few ways to measure the body’s toxic load and assess the effectiveness of chelation therapy:

Heavy Metal Testing: This can be done through blood, urine, or hair sample analysis. Before chelation therapy, a baseline measurement of heavy metal levels is taken. Then, additional measurements are taken to see if levels have decreased during or after therapy.

Chelation Challenge Test: A chelating agent is administered, followed by a urine collection over 24 hours. The urine is then tested for heavy metals. This test can reveal hidden stores of heavy metals in the body that aren’t apparent in a regular heavy metal test.

Other Lab Tests: Lab tests such as complete blood count, liver function tests, and kidney function tests can also indicate how well the body handles the toxin load and how effective chelation therapy is. These tests can identify any strain or damage to these organs caused by heavy metals.

Remember, though, that all medical procedures and tests should be conducted under the guidance of a qualified healthcare provider to ensure safety and effectiveness.

Kidney Function

several ingredients found in modern chelation support supplements may provide beneficial effects.

EDTA, or Ethylene Diamine Tetraacetic Acid, is a chelating agent known for its ability to bind to heavy metals in the body, which can potentially aid in their removal and thereby reduce the toxic burden on the kidneys. A study published in Biomedical Research International suggested the potential benefit of EDTA.

Chlorella Algae, known for its detoxifying properties, has also shown promise in improving renal function. Specifically, a study in the Journal of Medicinal Food suggested that Chlorella might improve renal function in dialysis patients by reducing the absorption of toxic substances in the intestines.

Modified Citrus Pectin, a specialized form of pectin, may be able to bind to and facilitate the excretion of a range of toxins, including heavy metals. This could potentially reduce the burden these toxins place on the kidneys, as highlighted in a study published in Phytotherapy Research.

Brain Detox

In terms of neurological function, several unique ingredients may provide support. For instance, EDTA may potentially reduce the neurotoxic effects of heavy metals by aiding in their removal. The accumulation of heavy metals in the brain has been linked to neurological conditions like Alzheimer’s disease.

Although more research is necessary, a review in the Journal of Alzheimer’s Disease discussed the potential benefits of chelation for Alzheimer’s disease.

Alpha Lipoic Acid, an antioxidant, has been associated with potential neurological benefits. A journal CNS & Neurological Disorders – Drug Targets review suggested that Alpha Lipoic Acid might offer neuroprotective effects in conditions such as multiple sclerosis and Alzheimer’s disease.

Lastly, Shilajit, a traditional Ayurvedic compound, has been associated with neuroprotective properties. A study in the Journal of Ethnopharmacology found that Shilajit helped improve memory and cognitive functions in rats, suggesting potential neurological benefits.

Remember that while these studies suggest potential benefits, they are not 100% definitive proof, and more research, including human trials, must be done to be definitive. Always make sure you consult with a healthcare provider before starting any new supplement program.

Liver Detox

The liver plays a key role in detoxification within the body. One of its main jobs is to filter out harmful substances from the bloodstream. When unhealthy heavy metals enter the bloodstream, it is the liver’s responsibility to help remove them, which can tax your system. Chelation therapy may support liver health by aiding in detoxification and reducing the overall toxic burden on the liver.

Here are some specifics on things that have been studied for their potential to support liver health:

  1. EDTA (Ethylene Diamine Tetraacetic Acid): As a chelating agent, EDTA binds to heavy metals and helps remove them from the body. This can potentially reduce the strain on the liver, which otherwise would have to work harder to remove these toxins. A study published in the Journal of Inorganic Biochemistry demonstrated the ability of EDTA to chelate cadmium and reduce its toxic effects in the liver, potentially preserving liver health 13.
  2. Milk Thistle Seed Powder: Milk thistle is known for its hepatoprotective properties, which can protect the liver from damage. A review published in the Journal of Veterinary Internal Medicine reported that silymarin, an active compound in milk thistle, can help protect the liver from toxins, including certain heavy metals 14.
  3. NAC (N-Acetyl Cysteine): NAC is a powerful and well-known antioxidant that can help to neutralize harmful free radicals in the body. A World Journal of Gastroenterology study reported that NAC may help reduce liver damage caused by various toxic substances, including heavy metals 15.

Chelation Supplements: A Preventive Measure for Health, Not a Cure for Severe Disease

Chelation therapy can often be misunderstood when implemented via oral supplements (oral chelation). Chelation supplements are preventative, not a panacea or cure-all, capable of curing severe diseases and chronic health conditions.

Oral chelation supplements, like Chelanox, are preventive measures that aim to reduce the toxic load in the body. They are not designed to cure severe diseases but rather to support overall health and potentially reduce the risk of certain health issues.

Chelation supplements work by binding to toxic metals in the body and aiding in their removal. These toxins, including heavy metals like lead, mercury, and arsenic, can build up over time due to various factors such as environmental pollution, consumption of certain foods, and exposure to some types of industrial work. Over time, this toxic load can contribute to many health issues, including cardiovascular disease, neurological disorders, and kidney damage. By helping to reduce this toxic load, chelation supplements can potentially support overall health and wellness.

Ingredients in chelation supplements like EDTA, Chlorella Algae, and Modified Citrus Pectin have been shown in studies to bind to toxins, potentially aiding their removal from the body. This does not mean they can cure diseases caused by these toxins, but they may help reduce the risk or severity of such diseases by limiting the body’s exposure to these harmful substances.

Chelation supplements can’t replace conventional treatments for severe diseases. Chelation supplements are not likely to reverse these conditions or act as a standalone cure for individuals with significant health conditions like late-stage cardiovascular disease, advanced kidney disease, or serious neurological disorders.

Severe diseases typically require comprehensive treatment plans overseen by healthcare professionals, including medication, lifestyle changes, and in some cases, surgical interventions.

However, the preventive aspect of chelation supplements really shines when they are used as a part of an overall health maintenance regimen. They may help the body manage and eliminate toxins more effectively, contributing to better overall health and potentially reducing the risk of certain diseases. This, combined with a healthy diet, regular exercise, and regular medical check-ups, can be a robust strategy for disease prevention and health promotion.

So, while chelation supplements like Chelanox can be a valuable addition to a health maintenance regimen, it’s crucial to understand their role. They are preventive, not curative, measures.

As always, it’s essential to consult with your healthcare provider before starting any new supplement regimen, particularly for individuals with existing health conditions or those on other medications. This ensures that the supplement will not interfere with any ongoing treatments or medications and that it’s a suitable addition to your personal healthcare plan.

The Efficacy of Vitamin D in Atrial Fibrillation Risk Reduction

Important Recent Study

Atrial fibrillation, aka a-fib, is a common heart rhythm disorder and is a significant concern, especially for older adults. It increases the risk of stroke, heart failure, and even death. Research over the years has shown light on the vital role of certain nutrients like Vitamin D in overall health and, more specifically, cardiovascular health.

A recent study from the University of Eastern Finland shows that a higher than recommended Vitamin D intake over an extended time can considerably mitigate the risk of atrial fibrillation in older adults. In layperson’s terms, it may support the prevention of a-fib. This fascinating revelation could have massive implications for preventative health strategies, highlighting the importance of ideal nutrition for heart health.

At Bionox, our Ultimate Nitric Oxide Nutrition offers a balanced blend of critical nutrients, including Vitamin D, to bolster heart health and overall well-being.* Since our company’s inception, we have understood the importance of Vitamin D.

The Finnish Vitamin D Trial

The study published in the American Heart Journal is based on the Finnish Vitamin D Trial (FIND) carried out from 2012 to 2018. The core objective of FIND was to examine the correlation between Vitamin D supplementation and the incidence of cardiovascular diseases and cancers.
The five-year study comprised 2,495 participants, including men aged 60 and above and women aged 65 and above. These participants were randomized into three groups: a placebo group and two Vitamin D3 supplementation groups. One group received 1,600 International Units (IU) daily, and the other received 3,200 IU daily of Vitamin D3. Additionally, all participants were permitted to take their Vitamin D supplement, up to 800 IU per day, which was the recommended dosage for this age group at the beginning of the study.
The study monitored the participants closely, providing detailed input on their lifestyle, nutrition, risk factors, and disease occurrence. Many participants were randomly selected for more in-depth examinations and blood tests.

Vitamin D: A Protective Shield

During the study, 190 participants were diagnosed with atrial fibrillation. Among them, 76 were from the placebo group, 59 from the 1,600 IU group, and 55 from the 3,200 IU group. Remarkably, the risk of atrial fibrillation was found to be 27% lower in the 1,600 IU group and 32% lower in the 3,200 IU group compared to the placebo group.

At the outset, the mean baseline serum calcidiol concentration, a marker of the body’s Vitamin D status, was relatively high at 75 nmol/l. After one year, the mean calcidiol concentration rose to 100 nmol/l in the 1,600 IU group and 120 nmol/l in the 3,200 IU group. Interestingly, the placebo group showed no significant change in the calcidiol concentration.

What sets this study apart is that it is the first randomized controlled trial that showed Vitamin D supplementation reduces the risk of atrial fibrillation in generally healthy men and women. Previously, only two randomized trials attempted to observe an effect but used relatively smaller doses of 400 IU or 2,000 IU per day. Although further research is warranted to validate these results, these findings are undeniably promising.

It’s important to note that the dosages of Vitamin D used in this study exceed the daily recommended values. Yet, they were shown to be safe and effective over the five years. This point emphasizes that Vitamin D, even at higher dosages, can be safely incorporated into our diet to provide significant health benefits potentially.

New Perspectives

Historically, the recommended daily Vitamin D intake was up to 800 International Units (IU) per day. This dose was considered adequate to fulfill the body’s needs and maintain good bone health. However, the Finnish Vitamin D Trial upends this conventional wisdom by demonstrating the safety and efficacy of what was previously considered ‘very high’ intakes of Vitamin D – doses of 1,600 IU and 3,200 IU per day.

The study participants who took these higher doses over five years demonstrated no adverse effects and exhibited a significantly lower risk of atrial fibrillation. These findings challenge the traditional view on Vitamin D dosage, suggesting that higher intakes could be both safe and beneficial in cardiovascular health.

As the scientific understanding of Vitamin D evolves, these ‘high’ intakes could become the new normal for optimal health and wellness.

Ultimate Nitric Oxide Nutrition by Bionox: The Vitamin D Advantage.

At Bionox, our Ultimate Nitric Oxide Nutrition amalgamates essential nutrients, including Vitamin D, to foster heart health. Vitamin D has shown its potential in reducing atrial fibrillation risk, and by integrating this vitamin at appropriate levels in our nutritional supplement, we aim to provide a comprehensive dietary solution to our consumers.

The Finnish Vitamin D Trial underlines the power of essential nutrients, like Vitamin D, in mitigating the risk of conditions such as atrial fibrillation. The research validates the effectiveness of a comprehensive nutritional strategy, as provided by Bionox’s Ultimate Nitric Oxide Nutrition, in promoting heart health and overall well-being.

Bionox continuously strives to integrate and apply insights from the latest scientific research into our products. By offering a unique blend of essential nutrients, we empower you to live a healthier and more vibrant life.

Besides the many benefits mentioned in this study, Vitamin D plays a vital role in many bodily functions, including supporting Nitric Oxide Synthase functions and subsequent Nitric Oxide production.
Nitric Oxide is a vital molecule in the body, influencing various physiological functions, including vasodilation – the widening of blood vessels. This process enhances blood flow and the supply of oxygen to tissues. Nitric Oxide Synthase is the enzyme that catalyzes the production of Nitric Oxide in our bodies.

Vitamin D influences Nitric Oxide Synthase in several ways. Firstly, it stimulates the production of Nitric Oxide Synthase, increasing Nitric Oxide synthesis. Additionally, there is evidence suggesting that Vitamin D could enhance the biological availability of Nitric Oxide by reducing oxidative stress. Oxidative stress can limit Nitric Oxide availability by transforming it into a harmful compound known as peroxynitrite. Vitamin D helps preserve Nitric Oxide by mitigating oxidative stress, upholding or extending its beneficial effects.

To learn more about the study visit

The Power of Fruit Extracts in Bionox's Ultimate Nitric Oxide Nutrition

When you look at the ingredients list on our Ultimate Nitric Oxide Nutrition label, adorned with our vibrant ‘river of fruit’ image, you might wonder: “Can fruit extracts truly be that powerful?” The answer, simply put, is a yes.

Each fruit extract in our unique blend has been selected not just for their mouth-watering taste, but more importantly for their potent health-promoting properties. Here’s a brief rundown of the fruits included in our formula, and how they can support your health, nitric oxide levels and more:

Pomegranate Extract: Pomegranates are rich in antioxidants, which are known to promote the production of nitric oxide.
Antioxidants also help protect the nitric oxide molecule helping it to last longer. Also, studies have shown that pomegranate extract may improve exercise performance, reduce muscle damage, and enhance blood flow by boosting and extending nitric oxide levels and lifespan.

Watermelon Extract: Watermelon is very high in the amino acid citrulline. Citrulline is converted into arginine in your body, which is then used in turn to create nitric oxide. Thus, watermelon extract can contribute to increased nitric oxide levels and improved vascular health.
Why not just add citrulline? Getting as many different types of citrulline as possible is important so while our formula has citrulline in it’s amino acid form, the watermelon form is going to be a little different. More options equates to more conversion into nitric oxide.

Blackberry Extract: Blackberries are high in vitamin C and fiber, but they also contain compounds that improve vascular function. This can aid in the promotion of nitric oxide production, improving blood flow and reducing blood pressure.

Raspberry Extract: Raspberries are rich in flavonoids and have anti-inflammatory and antioxidant properties. These compounds can stimulate the production of nitric oxide, which contributes to vascular health.

Grape Seed Skin Extract: Perhaps the most impressive of our fruit extracts, grape seed extract, has a wide range of benefits, from cardiovascular support to antioxidant protection. It contains high amounts of oligomeric proanthocyanidin complexes (OPCs) – powerful antioxidants that play a role in supporting nitric oxide synthase (NOS), the enzyme responsible for producing nitric oxide in our bodies. By encouraging the activity of NOS, grape seed extract contributes to higher nitric oxide levels, promoting better blood flow and overall cardiovascular health.

Camu Camu Berry: This superfruit is loaded with vitamin C and antioxidants. Current research suggests that the bioactive compounds in Camu Camu could potentially increase nitric oxide production, supporting heart health and immune function to mention just a few benefits.

As you can see, fruit extracts are far more than just flavor enhancers. They are packed with powerful compounds that help maintain optimal health and support nitric oxide production at the same time. When incorporated in the right way, as we do in Ultimate Nitric Oxide Nutrition, they can offer significant benefits to your overall health.

Vitamin K2 and Heart Health

Vitamin K2 and Heart Health

Introduction: The Essential Role of Vitamin K2

Vitamin K2 is a remarkable and essential nutrient, notable for its multifaceted contribution to our health. Predominantly recognized for its crucial role in heart health and bone preservation, Vitamin K2 is an under-appreciated vitamin that significantly influences our overall well-being. Found in a variety of foods such as cheese, liver, and egg yolks, this nutrient is often lacking in our daily consumption, making supplementation a practical solution for many. Ultimate Nitric Oxide Nutrition contains an effective 180 mcg dosage of Vitamin K2, perfectly geared to fulfill this dietary gap.

Vitamin K2: A Brief History

Vitamin K was first discovered in 1929 as an essential nutrient for blood coagulation. The letter ‘K’ comes from the German word ‘Koagulation.’ Vitamin K2 (menaquinone) was later distinguished as a member of the vitamin K series and was found to have distinct benefits separate from its Vitamin K1 counterpart [1]. With increasing research, it’s now evident that K2 plays a significant role in various bodily functions, from cardiovascular health to cognitive function.

Unpacking the Heart Health Benefits of Vitamin K2

A profound influence of Vitamin K2 is on heart health. Vitamin K2 carries the unique capacity to regulate calcium in the body – directing it towards the bones and teeth, where it’s required, and away from the arteries and veins, where it can cause calcification and potential cardiovascular diseases [2]. By inhibiting calcium deposits in arteries and veins, Vitamin K2 promotes the health and elasticity of these blood vessels, thus reducing heart disease risks.

Vitamin K2 and Heart Health

Understanding the Dosage: Why 180 mcg?

Optimal dosage recommendations for Vitamin K2 can differ depending on individual factors. However, research indicates that a daily intake of around 180 mcg for most adults ensures adequate utilization of this vitamin without risking overdosage [3]. This dosage provides a safe and effective means to harness the benefits of Vitamin K2 and maintain a healthy balance within the body.

The Influence of Vitamin K2 on Veins and Arteries

Vitamin K2 has a direct, significant impact on our veins and arteries. By activating a protein called Matrix GLA protein (MGP), K2 effectively inhibits calcium from depositing in the walls of blood vessels, ensuring their flexibility and healthy function [4]. The result is an essential reduction in vascular calcification, promoting healthy blood flow and decreasing the risk of various cardiovascular ailments.

Vitamin K2: Its Effects on the Brain

Emerging research suggests a promising role for Vitamin K2 in supporting brain health. Vitamin K is involved in the synthesis of sphingolipids, a type of fat abundant in brain cells, crucial for their health [5]. Furthermore, Vitamin K2’s role in calcium regulation can potentially prevent calcification and subsequent degradation of neural tissues, reducing the risk of neurodegenerative disorders such as Alzheimer’s disease.

Vitamin K2’s Potential Role in Cancer Prevention

Increasing evidence hints at Vitamin K2’s potential role in cancer prevention and treatment. Preliminary studies suggest that Vitamin K2 can inhibit the growth of various types of cancer cells [6]. While more extensive research is necessary in this field, the initial findings are indeed compelling.

Additional Benefits of Vitamin K2

Beyond its influence on heart health, veins, arteries, brain health, and potential cancer prevention, Vitamin K2 has a plethora of additional benefits. For instance, Vitamin K2’s role in bone health is noteworthy. It activates a protein called osteocalcin, which helps bind calcium to the bones, preventing conditions like osteoporosis [7].

Additionally, Vitamin K2 supports dental health by preventing calcium from accumulating and contributing to tooth decay [8]. Moreover, Vitamin K2 plays a role in supporting a healthy immune system and regulating blood sugar [9].

Is Vitamin K2 Safe?

Vitamin K2 is generally safe for most people when taken by mouth or injected into the vein appropriately. Most people can take it without any adverse side effects. However, each individual’s tolerance can vary, and it’s important to follow the recommended dosage guidelines and consult with a healthcare provider before starting any new supplement regimen [10].

American Heart Association Study

The American Heart Association’s published study reported that vitamin K2 supplements did not slow the progression of calcium deposits on the aortic valves in older men. This conclusion may indeed be disheartening to those hoping for a non-invasive method to mitigate aortic stenosis. However, it’s essential to interpret these results in the broader context of scientific research, which often includes conflicting findings and unexpected outcomes.

Firstly, the nature of scientific exploration dictates that single studies, even if randomized and double-blind, should not be seen as definitive. Each study has limitations and nuances that need to be considered. Also, a body of research is typically more significant than individual findings. Just because one study did not find an effect does not mean that the effect does not exist. It could mean that the effect was not detected due to various factors related to study design, population, dosage, timing, and so forth.

Next, it’s important to recognize that this study focused on individuals with already established aortic stenosis. The process of calcification had already begun in these individuals. The role of vitamin K2 might be more preventive than therapeutic, meaning it might have a more significant impact when taken before the onset of calcification, rather than after it has already occurred.

Moreover, this study focused on a relatively specific population: older men with aortic stenosis. The results may not necessarily apply to other groups, such as women, younger individuals, or those at risk of aortic stenosis but not yet diagnosed.

Lastly, the dosages and forms of vitamin K2 used in the study could also impact the results. Different forms of vitamin K2, such as MK-4 and MK-7, have different properties, including different half-lives in the body. The dosage used might not have been sufficient to make a noticeable impact on the progression of aortic stenosis.

So, while it’s essential to take this study into account, it is also crucial to consider the broader context and the limitations of the study. Future research should continue to explore the role of vitamin K2 in heart health, including its potential preventive role and its impact in different populations.